FR 900506对人T淋巴细胞同种异体激活的体外免疫抑制作用。
IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION.
作者信息
Zeevi A, Duquesnoy R, Eiras G, Todo S, Makowka L, Starzl T
机构信息
Departments of Pathology and Surgery, University of Pittsburgh School of Medicine.
出版信息
Surg Res Commun. 1987;1:315-323.
Abstract
FR 900506 (FR) is a new immunosuppressive drug which prolongs allograft survival. Our studies have compared the in vitro inhibitory effects of FR and Cyclosporine (CsA) on human lymphocyte proliferation. Considerably lower doses of FR were required to induce inhibition of lymphocyte proliferation induced by concanavalin A (ConA) stimulation or in primary mixed lymphocyte reactions (MLR) Similar differences between FR and CsA were observed with the secondary stimulation of alloactivated T cells generated in MLR or propagated from liver transplant biopsies These observations provide further evidence that FR is about 500 fold more potent than CsA and may be a useful immunosuppressive agent in organ transplantation.
摘要
FR 900506（FR）是一种新型免疫抑制药物，可延长同种异体移植物的存活时间。我们的研究比较了FR和环孢素（CsA）对人淋巴细胞增殖的体外抑制作用。在诱导刀豆球蛋白A（ConA）刺激或原发性混合淋巴细胞反应（MLR）所诱导的淋巴细胞增殖抑制方面，所需的FR剂量要低得多。在MLR中产生或从肝移植活检中传代的同种异体激活T细胞的二次刺激中，也观察到了FR和CsA之间的类似差异。这些观察结果进一步证明，FR的效力比CsA高约500倍，可能是器官移植中一种有用的免疫抑制剂。
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