Molyneaux Bradley J, Arlotta Paola, Menezes Joao R L, Macklis Jeffrey D
MGH-HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Nat Rev Neurosci. 2007 Jun;8(6):427-37. doi: 10.1038/nrn2151.
In recent years, tremendous progress has been made in understanding the mechanisms underlying the specification of projection neurons within the mammalian neocortex. New experimental approaches have made it possible to identify progenitors and study the lineage relationships of different neocortical projection neurons. An expanding set of genes with layer and neuronal subtype specificity have been identified within the neocortex, and their function during projection neuron development is starting to be elucidated. Here, we assess recent data regarding the nature of neocortical progenitors, review the roles of individual genes in projection neuron specification and discuss the implications for progenitor plasticity.
近年来，在理解哺乳动物新皮层内投射神经元特化的潜在机制方面取得了巨大进展。新的实验方法使得识别祖细胞并研究不同新皮层投射神经元的谱系关系成为可能。在新皮层中已经鉴定出一组不断扩大的具有层和神经元亚型特异性的基因，并且它们在投射神经元发育过程中的功能也开始得到阐明。在这里，我们评估了有关新皮层祖细胞性质的最新数据，回顾了个别基因在投射神经元特化中的作用，并讨论了祖细胞可塑性的意义。
