Yoshioka Jun, Schreiter Eric R, Lee Richard T
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Antioxid Redox Signal. 2006 Nov-Dec;8(11-12):2143-51. doi: 10.1089/ars.2006.8.2143.
The thioredoxin system helps maintain a reducing environment in cells, but thioredoxin functions as more than simply an antioxidant. Thioredoxin functions depend on the protein's redox state, as determined by two conserved cysteines. Key biologic activities of thioredoxin include antioxidant, growth control, and antiapoptotic properties, resulting from interaction with target molecules including transcription factors. Mechanisms by which thioredoxin regulates cell growth include binding to signaling molecules such as apoptosis signal-regulating kinase-1 (ASK-1) and thioredoxin-interacting protein (Txnip). The molecular interplay between thioredoxin, ASK-1, and Txnip potentially influences cell growth and survival in diverse human diseases such as cancer, diabetes, and heart disease. In this review, we focus on the structure of thioredoxin and its functional regulation of cell growth through the interactions with signaling molecules.
硫氧还蛋白系统有助于维持细胞内的还原环境，但硫氧还蛋白的功能不仅仅是简单的抗氧化作用。硫氧还蛋白的功能取决于由两个保守半胱氨酸决定的蛋白质氧化还原状态。硫氧还蛋白的关键生物学活性包括抗氧化、生长调控和抗凋亡特性，这些特性源于与包括转录因子在内的靶分子相互作用。硫氧还蛋白调节细胞生长的机制包括与信号分子如凋亡信号调节激酶-1（ASK-1）和硫氧还蛋白相互作用蛋白（Txnip）结合。硫氧还蛋白、ASK-1和Txnip之间的分子相互作用可能影响多种人类疾病如癌症、糖尿病和心脏病中的细胞生长和存活。在本综述中，我们重点关注硫氧还蛋白的结构及其通过与信号分子相互作用对细胞生长的功能调控。
