Hong Xuezhi, Tang Huiqing, Wu Limao, Li Lianda
Institute of Chinese Herb Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310031, PRC.
J Pharm Pharmacol. 2006 Oct;58(10):1391-8. doi: 10.1211/jpp.57.10.0013.
The aim of this investigation was to evaluate the efficacy of Alisma orientalis methanolic extract (AOME) on the experimental nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet. Rats were fed with high-fat diet for six weeks and then gavaged the AOME for another six weeks. Typical pathological symptoms of NAFLD occurred in the high-fat diet rats. Administration with the AOME (150,300 and 600 mg kg (-1)) markedly decreased the serum and liver lipids; the high level of fasting serum glucose was reduced and insulin resistance was improved. The AOME treatment was also helpful in preventing the oxidative stress by lessening lipid peroxidation and activating antioxidant enzymes. Markers of the liver injury, aminotransferase abnormalities and hepatomegaly were improved and morphological changes, such as liver steatosis, mixed inflammation and collagen deposition, were lessened in rats treated with the AOME. These results suggested that the AOME showed hepatoprotective effects on NAFLD and may be a potential clinical application for treatment of this chronic liver disease.
本研究旨在评估泽泻甲醇提取物（AOME）对高脂饮食诱导的实验性非酒精性脂肪性肝病（NAFLD）的疗效。大鼠喂食高脂饮食六周，然后再灌胃AOME六周。高脂饮食大鼠出现了典型的NAFLD病理症状。给予AOME（150、300和600 mg kg(-1)）可显著降低血清和肝脏脂质；空腹血清葡萄糖水平降低，胰岛素抵抗得到改善。AOME治疗还通过减轻脂质过氧化和激活抗氧化酶来预防氧化应激。肝损伤标志物、转氨酶异常和肝肿大得到改善，AOME治疗的大鼠肝脏脂肪变性、混合性炎症和胶原沉积等形态学变化减轻。这些结果表明，AOME对NAFLD具有肝脏保护作用，可能是治疗这种慢性肝病的潜在临床应用药物。
