Lu Chung-Yen, Ma Yee-Chung, Lin Jia-Min, Chuang Chun-Yu, Sung Fung-Chang
Institute of Environmental Health, National Taiwan University College of Public Health, Taipei, Taiwan.
Environ Res. 2007 Mar;103(3):331-7. doi: 10.1016/j.envres.2006.08.009. Epub 2006 Oct 10.
This study investigated whether urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of oxidative stress, was associated with indoor air quality for non-smokers in high-rise building offices. With informed consents, urine samples from 344 non-smoking employees in 86 offices were collected to determine 8-OHdG concentrations. The concentrations of carbon dioxide (CO(2)) and total volatile organic compounds (TVOCs) in each office and outside of the building were simultaneously measured for eight office hours. The average workday difference between indoor and outdoor CO(2) concentrations (dCO(2)) was used as a surrogate measure of the ventilation efficiency for each office unit. The CO(2) levels in the offices ranged 467-2810ppm with a mean of 1170ppm, or 2.7 times higher than that in the outside air. The average urinary 8-OHdG levels among employees increased from 3.10 micro g/g creatinine, for those at the lowest tertile levels of both dCO(2) and TVOCs, to 6.27 micro g/g creatinine, for those at the highest tertile levels. Multivariate logistic regression analysis showed that the risk of having the urinary 8-OHdG level of greater than the median, 4.53 micro g/g creatinine, for participants was increased significantly at the highest tertile dCO(2) level of >680ppm (odds ratio (OR)=3.37, 95% confidence interval (CI)=1.20-9.46). The effect was significant at the middle tertile TVOCs level of 114-360ppb (OR=2.62, 95% CI=1.43-4.79), but not at the highest tertile. Inadequate ventilation in office increases the risk of building-related oxidative stress in non-smoking employees.
本研究调查了氧化应激生物标志物尿8-羟基脱氧鸟苷（8-OHdG）是否与高层建筑办公室非吸烟人群的室内空气质量相关。在获得知情同意后，收集了86间办公室344名非吸烟员工的尿液样本，以测定8-OHdG浓度。在八个办公小时内，同时测量了每间办公室及建筑物外的二氧化碳（CO₂）和总挥发性有机化合物（TVOCs）浓度。各办公室单位的室内外CO₂浓度平均工作日差值（dCO₂）用作通风效率的替代指标。办公室内的CO₂水平在467 - 2810ppm之间，平均为1170ppm，是室外空气的2.7倍。员工中尿8-OHdG的平均水平从dCO₂和TVOCs处于最低三分位数水平的人群的3.10μg/g肌酐，增加到处于最高三分位数水平人群的6.27μg/g肌酐。多因素逻辑回归分析显示，对于参与者而言，在最高三分位数dCO₂水平>680ppm时，尿8-OHdG水平高于中位数4.53μg/g肌酐的风险显著增加（优势比（OR）=3.37，95%置信区间（CI）=1.20 - 9.46）。在TVOCs处于中间三分位数水平114 - 360ppb时该效应显著（OR=2.62，95%CI=1.43 - 4.79），但在最高三分位数水平时不显著。办公室通风不足会增加非吸烟员工与建筑物相关的氧化应激风险。
