Parklak Wason, Chuljerm Hataichanok, Kawichai Sawaeng, Fakfum Puriwat, Jiraya Putita, Kijkuokool Praporn, Khiaolaongam Wiritphon, Ngamsang Pakaphorn, Ounjaijean Sakaewan, Rerkasem Kittipan, Kulprachakarn Kanokwan
Research Center for Non-Infectious Diseases and Environmental Health, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Toxics. 2025 Apr 22;13(5):325. doi: 10.3390/toxics13050325.
Exposure to fine particulate matter (PM2.5) is linked to increased systemic inflammation, particularly in individuals with metabolic syndrome (MS). This study assessed the impact of nutrition and PM2.5 exposure on inflammatory markers in individuals with MS. A total of 50 participants (25 with MS, 25 healthy controls) were monitored during a high-PM2.5 exposure period (HEP) and a low-PM2.5 exposure period (LEP). Dietary intake, health assessments, and inflammatory markers-TNF-α, IL-6, and CRP-were evaluated. The MS group had significantly higher BMI, fasting blood glucose, and triglyceride levels and lower HDL-C than the healthy group ( < 0.01), but these parameters did not change significantly between the HEP and LEP. Notably, dietary fiber intake increased in the MS group during the LEP ( < 0.05). CRP levels were higher in the MS group and significantly decreased in both groups during the LEP ( < 0.05). IL-6 was higher in the MS group during the HEP but did not significantly change across periods. TNF-α showed no differences. Dietary fiber intake was inversely correlated with IL-6 and CRP in the healthy group and strongly correlated with CRP in the MS group ( = -0.403, < 0.01). Antioxidant vitamins were inversely correlated with inflammation only in healthy participants. These findings suggest that an increased dietary fiber intake may help reduce PM2.5-induced inflammation, particularly in individuals with MS.
暴露于细颗粒物（PM2.5）与全身炎症增加有关，尤其是在患有代谢综合征（MS）的个体中。本研究评估了营养和PM2.5暴露对MS患者炎症标志物的影响。在高PM2.5暴露期（HEP）和低PM2.5暴露期（LEP）对总共50名参与者（25名MS患者，25名健康对照）进行了监测。评估了饮食摄入量、健康状况以及炎症标志物——肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和C反应蛋白（CRP）。MS组的体重指数、空腹血糖和甘油三酯水平显著高于健康组，高密度脂蛋白胆固醇水平低于健康组（<0.01），但这些参数在HEP和LEP之间没有显著变化。值得注意的是，MS组在LEP期间膳食纤维摄入量增加（<0.05）。MS组的CRP水平较高，且在LEP期间两组的CRP水平均显著下降（<0.05）。MS组在HEP期间IL-6水平较高，但在不同时期没有显著变化。TNF-α没有差异。在健康组中，膳食纤维摄入量与IL-6和CRP呈负相关，在MS组中与CRP呈强相关（=-0.403，<0.01）。抗氧化维生素仅在健康参与者中与炎症呈负相关。这些发现表明，增加膳食纤维摄入量可能有助于减轻PM2.5引起的炎症，尤其是在MS患者中。
