Yasuda Masahiro, Takanashi Motoko, Nasu Tetsuo, Murakami Takayuki
Department of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, 1-1 Kibanadai-nishi, Miyazaki 889-2192, Japan.
Comp Immunol Microbiol Infect Dis. 2006 Nov;29(5-6):279-93. doi: 10.1016/j.cimid.2006.07.001. Epub 2006 Oct 10.
The development and distribution of lymphocyte subsets in calf palatine and pharyngeal tonsil were examined. During prenatal development, B cells were distributed in the subepithelial area, and T cells and MHC class II(+) cells were found in the deep layer of B-cell area, respectively, in both tonsils. At neonatal stage, lymphoid follicle containing a few CD4(+) cells have been formed in both tonsils. IgG(+) and IgA(+) cells were found in the parafollicular and epithelial area. At 3 months old, many germinal centers were recognized in both tonsils. CD4(+) cells and IgG mRNA expression were detected in light zone of germinal centers. Many IgG, and IgA mRNA expressions also could be detected in the parafollicular and subepithelial area of both tonsils. The data suggest that both tonsils have an important role of local immune defense against invading antigen after birth. The comparison of the histological characteristics of tonsil and Peyer's patch during ontogeny is also discussed.
研究了犊牛腭扁桃体和咽扁桃体中淋巴细胞亚群的发育和分布。在产前发育过程中，两个扁桃体的B细胞均分布于上皮下区域，T细胞和MHC II类（+）细胞分别位于B细胞区域的深层。在新生阶段，两个扁桃体均已形成含有少量CD4（+）细胞的淋巴滤泡。在滤泡旁和上皮区域发现了IgG（+）和IgA（+）细胞。3月龄时，两个扁桃体均可见许多生发中心。在生发中心的明区检测到CD4（+）细胞和IgG mRNA表达。在两个扁桃体的滤泡旁和上皮下区域也可检测到许多IgG和IgA mRNA表达。数据表明，两个扁桃体在出生后对入侵抗原的局部免疫防御中具有重要作用。还讨论了扁桃体和派伊尔结在个体发育过程中的组织学特征比较。
