Interhemispheric transfer time and structural properties of the corpus callosum.

The present study examined how interhemispheric transfer time (IHTT) is affected by interindividual differences in corpus callosum (CC) architecture. For this purpose the CC of 42 healthy male subjects was assessed by applying a combination of morphological and diffusion-tensor magnetic resonance imaging to characterize the CC on macro- (midsagittal area) and microstructural level (mean diffusion, fractional anisotropy). Following the so-called Poffenberger paradigm, IHTT was determined with both reaction time measures and event-related potentials recorded in response to stimuli briefly presented to either left or right visual hemifield. Statistical analysis revealed significant negative correlations between mean diffusion and IHTT estimates derived from the P100 component (at O1/O2 electrode pair), particularly in the posterior CC subregion. Interpreting mean diffusion as an index of microstructural tissue properties, IHTT appears to be directly related to the structural integrity of the posterior CC.