Westerhausen René, Kreuder Frank, Dos Santos Sequeira Sarah, Walter Christof, Woerner Wolfgang, Wittling Ralf Arne, Schweiger Elisabeth, Wittling Werner
Center for Neuropsychological Research, University of Trier, Germany.
Brain Lang. 2006 Apr;97(1):80-90. doi: 10.1016/j.bandl.2005.07.133. Epub 2005 Sep 12.
The present study aimed to examine how differences in functional lateralisation of language are related to interindividual variations in interhemispheric connectivity. Utilising an fMRI silent word-generation paradigm, 89 left- and right-handed subjects were subdivided into four lateralisation subgroups. Applying morphological and diffusion-tensor MRI, midsagittal cross-sectional area as well as quantitative measures of molecular diffusion (anisotropy, mean diffusion) of the corpus callosum were determined to assess interhemispheric connectivity. Statistical analyses revealed group differences in molecular diffusion but not in callosal size, which may be interpreted to reflect a stronger and/or faster interhemispheric connection in strongly left-lateralised subjects as compared to moderately left-lateralised, bilateral, or moderately right-lateralised subjects.
本研究旨在探讨语言功能偏侧化的差异如何与半球间连接的个体差异相关。利用功能磁共振成像（fMRI）的无声单词生成范式，将89名左利手和右利手受试者分为四个偏侧化亚组。应用形态学和扩散张量磁共振成像，测定胼胝体的矢状中截面积以及分子扩散的定量指标（各向异性、平均扩散），以评估半球间连接。统计分析显示，分子扩散存在组间差异，但胼胝体大小无差异，这可能意味着与中度左利手、双侧或中度右利手受试者相比，强左利手受试者的半球间连接更强和/或更快。
