Debeljuk L
J Endocrinol. 1975 Jul;66(1):53-60. doi: 10.1677/joe.0.0660053.
The effect of the depletion of germinal cells from the seminiferous tubules on serum follicle-stimulating (FSH) and luteinizing (LH) was studied in young male rats. A single administration of 1-(N,N-diethylcarbamylmethyl)-2-4-dinitropyrrole (ORF 1616) seemed to damage primary spermatocytes and especially young spermatids. Whenever young spermatids (stages 1-8) were absent or at least decreased in number, a significant increase in serum FSH, and in some cases serum LH, was detected. The administration of another drug, bis (dichloroacetyl) diamine (WIN 18446) for 21 consecutive days induced a depletion of primary spermatocytes in the seminiferous tubules, which was followed by a depletion of spermatids, due to the lack of spermatocytes to generat them. By the time the seminiferous tubules showed partial or total disapperance of young spermatids, serum FSH and in some cases also serum LH levels were significantly raised. It is concluded that the germinal epithelium of rat testes exerts some kind of control on serum gonadotrophin levels. Young spermatids seem to be involved in this regulation.
在年轻雄性大鼠中研究了生精小管中生发细胞耗竭对血清促卵泡激素（FSH）和促黄体生成素（LH）的影响。单次给予1-（N，N-二乙基氨甲酰甲基）-2,4-二硝基吡咯（ORF 1616）似乎会损伤初级精母细胞，尤其是年轻的精子细胞。每当年轻的精子细胞（1-8期）缺失或数量至少减少时，血清FSH会显著升高，在某些情况下血清LH也会升高。连续21天给予另一种药物双（二氯乙酰）二胺（WIN 18446）会导致生精小管中的初级精母细胞耗竭，随后由于缺乏精母细胞来产生精子细胞，精子细胞也会耗竭。当生精小管显示年轻精子细胞部分或完全消失时，血清FSH以及在某些情况下血清LH水平会显著升高。结论是，大鼠睾丸的生精上皮对血清促性腺激素水平发挥某种控制作用。年轻的精子细胞似乎参与了这种调节。
