严重急性呼吸综合征冠状病毒非结构蛋白1在趋化因子失调中的作用
Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation.
作者信息
Law Anna H Y, Lee Davy C W, Cheung Benny K W, Yim Howard C H, Lau Allan S Y
机构信息
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China.
出版信息
J Virol. 2007 Jan;81(1):416-22. doi: 10.1128/JVI.02336-05. Epub 2006 Oct 11.
Abstract
Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-kappaB.
摘要
严重急性呼吸综合征（SARS）是一种由新型冠状病毒引起的新发传染病。鉴于其相关的发病率和死亡率被认为是由于免疫失调所致，我们研究了哪种病毒蛋白导致趋化因子过度表达。为了阐明病毒与细胞因子的相互作用，我们从细胞因子诱导方面研究了四种严重急性呼吸综合征冠状病毒蛋白的作用，包括非结构蛋白1（nsp-1）、nsp-5、包膜蛋白和膜蛋白。我们的结果表明，严重急性呼吸综合征冠状病毒nsp-1通过激活核因子κB在人肺上皮细胞中CCL5、CXCL10和CCL3的表达中发挥重要作用。
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