成瘾与唤醒：下丘脑肽的其他作用
Addiction and arousal: alternative roles of hypothalamic peptides.
作者信息
de Lecea Luis, Jones Barbara E, Boutrel Benjamin, Borgland Stephanie L, Nishino Seiji, Bubser Michael, DiLeone Ralph
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
J Neurosci. 2006 Oct 11;26(41):10372-5. doi: 10.1523/JNEUROSCI.3118-06.2006.
Abstract
The importance of the lateral hypothalamus in the regulation of reward and motivation has long been recognized. However, the neuronal network involved in such a hypothalamic regulation of reward remains essentially unknown. Recently, hypocretin-containing neurons, a group of hypothalamic neurons known to be associated with the stability of arousal, have emerged as important structures in the control of brain reward function. This review summarizes a Mini-Symposium presented at the 2006 Annual Meeting of the Society for Neuroscience.
摘要
外侧下丘脑在奖赏和动机调节中的重要性早已得到认可。然而，参与这种下丘脑奖赏调节的神经网络基本上仍不为人所知。最近，含有下丘脑分泌素的神经元，即一组已知与觉醒稳定性相关的下丘脑神经元，已成为控制大脑奖赏功能的重要结构。本综述总结了在2006年神经科学学会年会上举办的一个小型研讨会的内容。
相似文献
1
Addiction and arousal: alternative roles of hypothalamic peptides.成瘾与唤醒：下丘脑肽的其他作用
J Neurosci. 2006 Oct 11;26(41):10372-5. doi: 10.1523/JNEUROSCI.3118-06.2006.
2
Arousal and reward: a dichotomy in orexin function.觉醒与奖赏：食欲素功能的二分法
Trends Neurosci. 2006 Oct;29(10):571-7. doi: 10.1016/j.tins.2006.08.002. Epub 2006 Aug 14.
3
Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons.食欲素B/下丘脑分泌素2增强向腹侧被盖区神经元的谷氨酸能传递。
Eur J Neurosci. 2008 Oct;28(8):1545-56. doi: 10.1111/j.1460-9568.2008.06397.x. Epub 2008 Sep 10.
4
Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices.去甲肾上腺素和乙酰胆碱对大鼠下丘脑切片中促食欲素/食欲素神经元与促黑素聚集激素神经元的相反作用。
Neuroscience. 2005;130(4):807-11. doi: 10.1016/j.neuroscience.2004.10.032.
5
Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structures.下丘脑泌素/食欲素向蓝斑及基底前脑觉醒相关结构的传出纤维组织。
J Comp Neurol. 2005 Jan 10;481(2):160-78. doi: 10.1002/cne.20369.
6
Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect.腺苷通过下丘脑外侧的A1受体抑制下丘脑分泌素/食欲素神经元的活性：一种可能的促进睡眠作用。
J Neurophysiol. 2007 Jan;97(1):837-48. doi: 10.1152/jn.00873.2006. Epub 2006 Nov 8.
7
Fast sensory representations in the lateral hypothalamus and their roles in brain function.外侧下丘脑的快速感觉表征及其在脑功能中的作用。
Physiol Behav. 2020 Aug 1;222:112952. doi: 10.1016/j.physbeh.2020.112952. Epub 2020 May 20.
8
A role for lateral hypothalamic orexin neurons in reward seeking.外侧下丘脑食欲素神经元在奖赏寻求中的作用。
Nature. 2005 Sep 22;437(7058):556-9. doi: 10.1038/nature04071. Epub 2005 Aug 14.
9
Alertness and feeding behaviors in ADHD: does the hypocretin/orexin system play a role?注意缺陷多动障碍中的警觉性与进食行为：下丘脑泌素/食欲素系统起作用吗？
Med Hypotheses. 2008 Nov;71(5):770-5. doi: 10.1016/j.mehy.2008.06.017. Epub 2008 Aug 3.
10
Function and dysfunction of hypocretin/orexin: an energetics point of view.下丘脑泌素/食欲素的功能和失调：能量学观点。
Annu Rev Neurosci. 2014;37:101-16. doi: 10.1146/annurev-neuro-071013-013855. Epub 2014 Apr 24.
引用本文的文献
1
Control and coding of pupil size by hypothalamic orexin neurons.下丘脑食欲素神经元对瞳孔大小的控制和编码。
Nat Neurosci. 2023 Jul;26(7):1160-1164. doi: 10.1038/s41593-023-01365-w. Epub 2023 Jun 19.
2
Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice.伏隔核回路抑制外侧下丘脑谷氨酸能神经元，有助于雄性小鼠的吗啡戒断记忆。
Nat Commun. 2023 Jan 5;14(1):71. doi: 10.1038/s41467-022-35758-5.
3
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer's Disease and Cognitively Normal Healthy Controls.下丘脑功能连接与阿尔茨海默病患者和认知正常健康对照者的淡漠
J Alzheimers Dis. 2022;90(4):1615-1628. doi: 10.3233/JAD-220708.
4
Hypothalamic Control of Forelimb Motor Adaptation.下丘脑对前肢运动适应的控制。
J Neurosci. 2022 Aug 10;42(32):6243-6257. doi: 10.1523/JNEUROSCI.0705-22.2022. Epub 2022 Jul 5.
5
The effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity.雄激素剥夺对前列腺癌患者工作记忆和生活质量的影响：下丘脑连接的作用。
Cancer Med. 2022 Sep;11(18):3425-3436. doi: 10.1002/cam4.4704. Epub 2022 Mar 22.
6
Neurobiological and Neurophysiological Mechanisms Underlying Nicotine Seeking and Smoking Relapse.尼古丁寻求和吸烟复发背后的神经生物学和神经生理学机制。
Mol Neuropsychiatry. 2019 Feb;4(4):169-189. doi: 10.1159/000494799. Epub 2018 Nov 19.
7
General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.神经元共传递的一般原则：来自多种模型系统的见解。
Front Neural Circuits. 2019 Jan 21;12:117. doi: 10.3389/fncir.2018.00117. eCollection 2018.
8
Rat behavior and dopamine release are modulated by conspecific distress.大鼠的行为和多巴胺释放受同物种痛苦的调节。
Elife. 2018 Nov 28;7:e38090. doi: 10.7554/eLife.38090.
9
Arousal and drug abuse.觉醒与药物滥用。
Behav Brain Res. 2017 Aug 30;333:276-281. doi: 10.1016/j.bbr.2017.07.013. Epub 2017 Jul 17.
10
A Role for Astrocytes in Sensing the Brain Microenvironment and Neuro-Metabolic Integration.星形胶质细胞在感知脑微环境和神经代谢整合中的作用。
Neurochem Res. 2015 Dec;40(12):2386-93. doi: 10.1007/s11064-015-1562-9. Epub 2015 Apr 3.
本文引用的文献
1
Natural history, symptoms and treatment of the narcoleptic syndrome.发作性睡病综合征的自然病史、症状及治疗
Acta Neurol Scand. 1975 Nov;52(5):337-53. doi: 10.1111/j.1600-0404.1975.tb05830.x.
2
A putative flip-flop switch for control of REM sleep.一种用于控制快速眼动睡眠的假定触发器开关。
Nature. 2006 Jun 1;441(7093):589-94. doi: 10.1038/nature04767. Epub 2006 May 10.
3
Phasic dopamine signaling during behavior, reward, and disease states.行为、奖励和疾病状态下的阶段性多巴胺信号传导。
CNS Neurol Disord Drug Targets. 2006 Feb;5(1):99-108. doi: 10.2174/187152706784111605.
4
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.腹侧被盖区中的食欲素A对于可卡因诱导的突触可塑性和行为敏化至关重要。
Neuron. 2006 Feb 16;49(4):589-601. doi: 10.1016/j.neuron.2006.01.016.
5
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.食欲素能系统直接参与中脑边缘多巴胺通路的激活以及吗啡诱导的相关行为。
J Neurosci. 2006 Jan 11;26(2):398-405. doi: 10.1523/JNEUROSCI.2761-05.2006.
6
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.下丘脑泌素在介导应激诱导的可卡因觅求行为复燃中的作用。
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73. doi: 10.1073/pnas.0507480102. Epub 2005 Dec 15.
7
A role for lateral hypothalamic orexin neurons in reward seeking.外侧下丘脑食欲素神经元在奖赏寻求中的作用。
Nature. 2005 Sep 22;437(7058):556-9. doi: 10.1038/nature04071. Epub 2005 Aug 14.
8
The neural basis of addiction: a pathology of motivation and choice.成瘾的神经基础：动机与选择的一种病理学。
Am J Psychiatry. 2005 Aug;162(8):1403-13. doi: 10.1176/appi.ajp.162.8.1403.
9
Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle.在睡眠-觉醒周期中，已鉴定的食欲素/下丘脑泌素神经元的放电情况。
J Neurosci. 2005 Jul 13;25(28):6716-20. doi: 10.1523/JNEUROSCI.1887-05.2005.
10
Dopaminergic regulation of orexin neurons.食欲素神经元的多巴胺能调节
Eur J Neurosci. 2005 Jun;21(11):2993-3001. doi: 10.1111/j.1460-9568.2005.04121.x.
Zotero 插件