Vortherms Timothy A, Roth Bryan L
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Mol Interv. 2006 Oct;6(5):257-65. doi: 10.1124/mi.6.5.7.
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been used for divination and shamanism by the Mazatecs. Over the past decade or so, S. divinorum has been increasingly used recreationally. The neoclerodane diterpene salvinorin A is the active component of S. divinorum, and recently, the kappa opioid receptor (KOR) has been identified, in vitro and in vivo, as its molecular target. The discovery of KOR as the molecular target of salvinorin A has opened up many opportunities for drug discovery and drug development for a number of psychiatric and non-psychiatric disorders.
致幻植物鼠尾草（即“魔法薄荷”）是唇形科植物的一种，马萨特克人曾用它来进行占卜和萨满仪式。在过去十年左右的时间里，鼠尾草越来越多地被用于娱乐目的。新克罗烷二萜类化合物Salvinorin A是鼠尾草的活性成分，最近，κ阿片受体（KOR）在体外和体内均被确定为其分子靶点。KOR作为Salvinorin A分子靶点的发现，为多种精神疾病和非精神疾病的药物发现和药物开发带来了诸多机遇。
