在阿尔茨海默病小鼠模型中对斑块负荷进行体内测量。
In vivo measurement of plaque burden in a mouse model of Alzheimer's disease.
作者信息
Borthakur Arijitt, Gur Tamar, Wheaton Andrew J, Corbo Matthew, Trojanowski John Q, Lee Virginia M-Y, Reddy Ravinder
机构信息
Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA.
出版信息
J Magn Reson Imaging. 2006 Nov;24(5):1011-7. doi: 10.1002/jmri.20751.
Abstract
PURPOSE
To demonstrate an MRI method for directly visualizing amyloid-beta (Abeta) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T1rho relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain.
MATERIALS AND METHODS
We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T1rho via quantitative relaxometric maps.
RESULTS
A significant decrease in T1rho was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T1rho and the age of the animals.
CONCLUSION
T1rho relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice.
摘要
目的
展示一种用于在体内直接可视化APP/PS1转基因（tg）小鼠大脑中β淀粉样蛋白（Aβ）斑块的MRI方法，并表明T1rho弛豫率随tg小鼠大脑中与阿尔茨海默病（AD）相关的病理学改变而逐渐增加。
材料与方法
我们获取了过表达人类淀粉样前体蛋白的AD小鼠模型（APP/PS1）的体内MR图像，并通过定量弛豫测量图测量T1rho。
结果
与年龄匹配的对照相比，在12个月和18个月大的动物的皮质和海马中观察到T1rho显著降低。T1rho的变化与动物年龄之间也存在相关性。
结论
T1rho弛豫测量法可能是一种用于非侵入性确定APP/PS1小鼠中与AD相关病理学的灵敏方法。
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