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本文引用的文献

1
Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease.在APP[V717I]转基因小鼠（一种阿尔茨海默病模型）中对与铁相关的神经炎性斑块进行非侵入性活体磁共振成像检测。
Magn Reson Med. 2005 Mar;53(3):607-13. doi: 10.1002/mrm.20385.
2
In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent.在无造影剂的转基因小鼠中通过磁共振成像对阿尔茨海默病淀粉样斑块进行体内可视化。
Magn Reson Med. 2004 Dec;52(6):1263-71. doi: 10.1002/mrm.20266.
3
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents.在不使用造影剂的情况下，利用磁共振显微镜在阿尔茨海默病转基因小鼠模型中可视化β-淀粉样蛋白斑块。
Magn Reson Med. 2004 Sep;52(3):538-44. doi: 10.1002/mrm.20196.
4
Method for reduced SAR T1rho-weighted MRI.降低比吸收率的T1rho加权磁共振成像方法。
Magn Reson Med. 2004 Jun;51(6):1096-102. doi: 10.1002/mrm.20141.
5
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease.阿尔茨海默病转基因小鼠模型中神经病理学的磁共振成像评估
Magn Reson Med. 2004 Apr;51(4):794-8. doi: 10.1002/mrm.20038.
6
In vivo measurement of T1rho dispersion in the human brain at 1.5 tesla.在1.5特斯拉磁场下对人脑进行T1rho弥散的活体测量。
J Magn Reson Imaging. 2004 Apr;19(4):403-9. doi: 10.1002/jmri.20016.
7
T1rho-weighted MRI using a surface coil to transmit spin-lock pulses.使用表面线圈发射自旋锁定脉冲的T1rho加权磁共振成像。
J Magn Reson. 2004 Apr;167(2):306-16. doi: 10.1016/j.jmr.2004.01.007.
8
Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging.通过磁共振成像检测阿尔茨海默病小鼠模型中的淀粉样斑块。
Magn Reson Med. 2004 Mar;51(3):452-7. doi: 10.1002/mrm.10730.
9
Pulse sequence for multislice T1rho-weighted MRI.多层T1rho加权磁共振成像的脉冲序列。
Magn Reson Med. 2004 Feb;51(2):362-9. doi: 10.1002/mrm.10705.
10
Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging.使用磁共振显微成像技术检测转基因小鼠中的阿尔茨海默氏淀粉样蛋白。
Magn Reson Med. 2003 Aug;50(2):293-302. doi: 10.1002/mrm.10529.

在阿尔茨海默病小鼠模型中对斑块负荷进行体内测量。

In vivo measurement of plaque burden in a mouse model of Alzheimer's disease.

作者信息

Borthakur Arijitt, Gur Tamar, Wheaton Andrew J, Corbo Matthew, Trojanowski John Q, Lee Virginia M-Y, Reddy Ravinder

机构信息

Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA.

出版信息

J Magn Reson Imaging. 2006 Nov;24(5):1011-7. doi: 10.1002/jmri.20751.

DOI:10.1002/jmri.20751
PMID:17036339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2859034/
Abstract

PURPOSE

To demonstrate an MRI method for directly visualizing amyloid-beta (Abeta) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T1rho relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain.

MATERIALS AND METHODS

We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T1rho via quantitative relaxometric maps.

RESULTS

A significant decrease in T1rho was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T1rho and the age of the animals.

CONCLUSION

T1rho relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice.

摘要

目的

展示一种用于在体内直接可视化APP/PS1转基因（tg）小鼠大脑中β淀粉样蛋白（Aβ）斑块的MRI方法，并表明T1rho弛豫率随tg小鼠大脑中与阿尔茨海默病（AD）相关的病理学改变而逐渐增加。

材料与方法

我们获取了过表达人类淀粉样前体蛋白的AD小鼠模型（APP/PS1）的体内MR图像，并通过定量弛豫测量图测量T1rho。

结果

与年龄匹配的对照相比，在12个月和18个月大的动物的皮质和海马中观察到T1rho显著降低。T1rho的变化与动物年龄之间也存在相关性。

结论

T1rho弛豫测量法可能是一种用于非侵入性确定APP/PS1小鼠中与AD相关病理学的灵敏方法。