Laboratory of Bioactive Azaheterocycles, Institute of Biomedicine and Pharmacy, Russian-Armenian University, Hovsep Emin Str. 123, Yerevan 0051, Armenia.
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, The National Academy of Sciences of the Republic of Armenia, Azatutyan Ave. 26, Yerevan 0014, Armenia.
Molecules. 2023 Mar 22;28(6):2869. doi: 10.3390/molecules28062869.
A method for the technically easy-to-implement synthesis of deuterium-labeled pyrazolo[1,5-]pyrimidines and 1,2,4-triazolo[1,5-]pyrimidines have been developed. The regioselectivity of such transformations has been shown. H NMR and mass spectrometric methods have proved the quantitative nature of such transformations and the kinetics of deuterium exchange has been studied. Spectrally, at different temperatures (+30 °C, -10 °C and -15 °C), the kinetics of the process was studied both in CDOD and in deuterated alkali.
已经开发出一种技术上易于实施的合成氘标记的吡唑并[1,5-a]嘧啶和 1,2,4-三唑并[1,5-a]嘧啶的方法。已经显示了这种转化的区域选择性。H NMR 和质谱方法证明了这种转化的定量性质，并研究了氘交换的动力学。在不同温度（+30°C、-10°C 和-15°C）下，通过 CDOD 和氘化碱对该过程的动力学进行了光谱研究。
