1 Centralab of the Second Xiangya Hospital of Central South University, Changsha 410011, China.
2 Xiangya School of Medicine, Central South University, Changsha 410200, Hunan, China.
Exp Biol Med (Maywood). 2018 May;243(8):725-735. doi: 10.1177/1535370218772802.
Spider toxins are molecularly diverse and some display not only a strong antibacterial effect but also exhibit significant inhibition of tumor growth and promote tumor cell apoptosis. The aim of the present investigation was to explore different antitumor effects of the spider peptide toxin lycosin-I through different pathways at different concentrations. It was found that by inactivating STAT3 pathway, high concentrations of lycosin-I induce apoptosis in prostate cancer cells and low concentrations of lycosin-I inhibit the migration of prostate cancer cells. This finding provides favorable evidence for further study of the molecular diversity of spider toxins. Impact statement The spider peptide toxin has become an important research topic. These toxins are molecularly diverse and some display not only a strong antibacterial effect but also exhibit significant inhibition of tumor growth and promote tumor cell apoptosis. Inspired by previous studies, the present study aims to investigate the effects of different concentrations of lycosin-I on the invasiveness and apoptosis of human prostate cancer cells. The findings provide favorable evidence for further study of the molecular diversity of spider toxins.
蜘蛛毒素具有分子多样性，其中一些不仅具有很强的抗菌作用，而且还能显著抑制肿瘤生长并促进肿瘤细胞凋亡。本研究旨在探讨蜘蛛肽毒素 lycosin-I 通过不同浓度的不同途径产生的不同抗肿瘤作用。研究发现，高浓度的 lycosin-I 通过使 STAT3 通路失活诱导前列腺癌细胞凋亡，而低浓度的 lycosin-I 则抑制前列腺癌细胞的迁移。这一发现为进一步研究蜘蛛毒素的分子多样性提供了有利的证据。
