Milano Michael, Lee Jessica Y, Donovan Katherine, Chen Jung-Wei
Department of Pediatric Dentistry, University of North Carolina at Chapel Hill, USA.
Pediatr Dent. 2006 Sep-Oct;28(5):415-9.
The purpose of this study was to examine the relationship between the specific types of medication, length of use, frequency of use, and dosing time of day on the dental caries of children diagnosed with asthma.
Using a patient list from a previous study, surveys were mailed to the parents of 179 asthmatic children. The survey itself consisted of a table that asked 4 questions: (1) What combination of asthma medications was used by the subject? (2) How long were the medications used? (3) How often were the medications used? (4) What time of day were the medications used?
Of the 179 surveys that were mailed out, 156 were returned. Children who used their medication greater than twice daily were significantly more likely to experience dental disease in both the primary (odds ratio [OR]=2.56, 95% confidence interval [CI]=1.45-6.29) and mixed dentitions (OR=3.56, 95% CI 2.45-5.94).
Increased frequency of asthma medication use was associated with increased likelihood of caries experience. The time of day asthma medication was used was associated with increased likelihood of caries experience in children in the primary dentition. Duration of asthma medication use was associated with a decreased likelihood of caries experience in children in the mixed dentition.
本研究旨在探讨特定类型药物、用药时长、用药频率以及每日用药时间与诊断为哮喘的儿童龋齿之间的关系。
利用先前一项研究的患者名单，向179名哮喘儿童的家长邮寄调查问卷。调查问卷包含一个表格，其中有4个问题：（1）受试者使用了哪些哮喘药物组合？（2）用药时长是多久？（3）用药频率是怎样的？（4）药物是在一天中的什么时间使用的？
在寄出的179份调查问卷中，有156份被退回。每天用药超过两次的儿童在乳牙列（比值比[OR]=2.56，95%置信区间[CI]=1.45 - 6.29）和混合牙列（OR=3.56，95% CI 2.45 - 5.94）中患牙病的可能性显著更高。
哮喘药物使用频率增加与患龋齿的可能性增加有关。乳牙列儿童使用哮喘药物的时间与患龋齿的可能性增加有关。混合牙列儿童哮喘药物的使用时长与患龋齿的可能性降低有关。
