[少白细胞血小板浓缩物的制备：一种新型过滤系统的结果]

[Production of leukocyte-poor thrombocyte concentrates: results with a new kind of filter system].

作者信息

Böck M, Salat C, Greither L, Heim M U, Weindler R, Bilas A, Mempel W

机构信息

Transfusionszentrum (Med. Klinik III), Klinikum Grosshadern, Universität München.

出版信息

Beitr Infusionsther. 1990;26:103-5.

PMID:1703804

Abstract

A newly developed filter-system (Sepacell PL) for the removal of leukocytes from single donor platelet concentrates was tested. It removes contaminating leukocytes by 99.9%, the platelet loss was calculated as less than 1%. Platelet ultrastructure and function do not seem to be altered by the filtration. Therefore, the tested filter system seems to be a suitable device for leukocyte depletion of single donor platelet concentrates. Further clinical studies, however, are necessary to prove the efficiency of the filter system in preventing alloimmunization in vivo.

摘要

对一种新开发的用于从单采血小板浓缩物中去除白细胞的过滤系统（Sepacell PL）进行了测试。它能去除99.9%的污染白细胞，计算得出的血小板损失小于1%。过滤似乎不会改变血小板的超微结构和功能。因此，所测试的过滤系统似乎是一种适用于单采血小板浓缩物白细胞去除的装置。然而，还需要进一步的临床研究来证明该过滤系统在体内预防同种免疫的有效性。