Kroll H, Kiefel V, Mueller-Eckhardt G, Santoso S, Mueller-Eckhardt C
Institut für Klinische Immunologie und Transfusionsmedizin, Justuts-Liebig-Universität Giessen.
Beitr Infusionsther. 1990;26:397-400.
The sera of 219 Zwa-positive mothers who gave birth to children with clinically suspected neonatal alloimmune thrombocytopenia (NAIT) were tested for platelet-reactive antibodies using the platelet adhesion immunofluorescence test and a glycoprotein-specific immunoassay (MAIPA). In 102 families a serological crossmatch of maternal serum against paternal platelets was performed. 12 sera contained platelet specific antibodies: Zwb (1), Bra (4), Bra and HLA (5), Baka and HLA (1), Sra (1); three further sera contained antibodies against blood group A (1), blood group B (1), blood group B and HLA (1). Anti-Bra was the most important antibody in this cohort. There is evidence that in certain cases antibodies against blood group antigens A or B may cause NAIT. Clinical data of NAIT duo to anti-Bra suggest a less severe bleeding tendency than in NAIT due to anti-Zwa. The HLA-DRw6 antigen was identified as an immunogenetic marker for the immunization against the Bra-antigen.
对219名Zwa阳性母亲的血清进行检测，这些母亲所生子女临床上疑似患有新生儿同种免疫性血小板减少症（NAIT），采用血小板黏附免疫荧光试验和糖蛋白特异性免疫分析（MAIPA）检测血小板反应性抗体。在102个家庭中，对母体血清与父体血小板进行了血清学交叉配型。12份血清含有血小板特异性抗体：Zwb（1份）、Bra（4份）、Bra和HLA（5份）、Baka和HLA（1份）、Sra（1份）；另有3份血清含有抗A血型（1份）、抗B血型（1份）、抗B血型和HLA（1份）的抗体。抗Bra是该队列中最重要的抗体。有证据表明，在某些情况下，抗A或B血型抗原的抗体可能导致NAIT。抗Bra所致NAIT的临床数据表明，其出血倾向比抗Zwa所致NAIT轻。HLA-DRw6抗原被确定为针对Bra抗原免疫的免疫遗传标志物。
