Maslanka K, Lucas G F, Gronkowska A, Davis J G, Zupanska B
Institute of Haematology, Warsaw, Poland.
Haematologia (Budap). 1989;22(2):109-13.
A case of neonatal alloimmune thrombocytopenia due to fetomaternal incompatibility against the platelet specific antigen PlA2 (Zwb) is described. Anti-PlA2 antibodies were present in the maternal serum together with anti-HLA antibodies. Initial identification of the platelet-specific antibodies was achieved by using chloroquine-treated PlA1(+) and PlA1(-) platelets. Antibody specificity was later confirmed using a panel of platelets of known phenotype.
本文描述了一例因胎儿与母亲血小板特异性抗原PlA2（Zwb）不相容导致的新生儿同种免疫性血小板减少症。母亲血清中存在抗PlA2抗体以及抗HLA抗体。通过使用氯喹处理的PlA1（+）和PlA1（-）血小板初步鉴定了血小板特异性抗体。随后使用一组已知表型的血小板确认了抗体特异性。
