Macedo A M, Pena S D
Parasitol Today. 1998 Mar;14(3):119-24. doi: 10.1016/s0169-4758(97)01179-4.
Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or even overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but genetic variation of both the host and parasite is likely to be important. Here, Andréa M. Macedo and Sérgio D.J. Pena review the evidence showing a role for the genetic constitution of T. cruzi in determining the clinical characteristics of Chagas disease, and propose a ;clonal-histotropic model' for the pathogenesis of this disease.
恰加斯病由原生动物克氏锥虫引起，其临床病程多变，从无症状感染到伴有心血管或胃肠道受累的严重慢性疾病，甚至是严重的急性发作。影响这种临床变异性的因素尚未阐明，但宿主和寄生虫的基因变异可能很重要。在此，安德烈娅·M·马塞多和塞尔吉奥·D·J·佩纳综述了表明克氏锥虫基因构成在决定恰加斯病临床特征中起作用的证据，并提出了该疾病发病机制的“克隆组织嗜性模型”。
