对疟原虫无性血液阶段的免疫：对急性疟疾的抗性是适应性的还是先天性的？
Immunity to asexual blood stages of Plasmodium: is resistance to acute malaria adaptive or innate?
作者信息
Fell A H, Smith N C
机构信息
Human Biology Program, Stanford University, CA 94305, USA.
出版信息
Parasitol Today. 1998 Sep;14(9):364-9. doi: 10.1016/s0169-4758(98)01298-8.
Abstract
Current models of immunity to blood stages of Plasmodium invoke a primary role for T-cell dependent processes and much recent evidence implicates Th1-type responses as crucial to the control of acute malaria. But do these data stand up to close scrutiny? Here, Andy Fell and Nick Smith review recent data from rodent and human studies and suggest that Th1-type responses may not after all be important in controlling malaria infection in the blood.
摘要
目前针对疟原虫血液阶段的免疫模型认为T细胞依赖性过程起主要作用，并且最近有很多证据表明Th1型反应对于控制急性疟疾至关重要。但这些数据经得起仔细推敲吗？在这里，安迪·费尔和尼克·史密斯回顾了来自啮齿动物和人类研究的最新数据，并指出Th1型反应在控制血液中的疟疾感染方面可能终究并不重要。
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