Luján H D, Mowatt M R, Nash T E
Cátedra de Quı́mica Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Parasitol Today. 1998 Nov;14(11):446-50. doi: 10.1016/s0169-4758(98)01333-7.
The protozoan parasite Giardia lamblia is transmitted as an environmentally resistant cyst. The encystation process is attracting attention not only from the viewpoint of disease transmission, but also as a model for differentiation. Here, Hugo Luján, Michael Mowatt and Theodore Nash discuss molecular events underlying this process, including the induction of expression and transport of cyst wall proteins and the induction of Golgi-like activity. They also propose that the signal for encystation derives from cholesterol deprivation in the lower small intestine.
原生动物寄生虫蓝氏贾第鞭毛虫以具有环境抗性的包囊形式传播。包囊形成过程不仅从疾病传播的角度受到关注，而且作为一种分化模型也备受瞩目。在此，雨果·卢扬、迈克尔·莫瓦特和西奥多·纳什讨论了这一过程背后的分子事件，包括包囊壁蛋白表达和运输的诱导以及类高尔基体活性的诱导。他们还提出，包囊形成的信号源自小肠下段的胆固醇缺乏。
