Daya D, Sabet L
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
Am J Clin Pathol. 1991 Feb;95(2):137-41. doi: 10.1093/ajcp/95.2.137.
The use of human chorionic gonadotropin (hCG), human placental lactogen (hPL), and pregnancy-specific beta-1-glycoprotein (SP1) as markers for trophoblastic tissue is well documented in the literature. However, it is not widely recognized that cytokeratin is a very sensitive and reliable marker for all types of trophoblastic tissues. The authors have studied 100 cases of human placental tissue ranging in age from 2 to 40 weeks. Unlike hCG and hPL, which stain only the syncytiotrophoblast and intermediate trophoblast, cytokeratin (AE1/AE3) stains all three types of trophoblastic tissue. The staining of placental tissue for cytokeratin is strong and very consistent throughout pregnancy. Because of its high sensitivity and ability to stain cytotrophoblast, it is believed that it could be very useful in the study of the pathologic process of implantation sites, especially in tissue obtained from patients who present with missed and habitual abortions.
人绒毛膜促性腺激素（hCG）、人胎盘催乳素（hPL）和妊娠特异性β1-糖蛋白（SP1）作为滋养层组织标志物的应用在文献中有充分记载。然而，细胞角蛋白作为所有类型滋养层组织非常敏感且可靠的标志物却未得到广泛认可。作者研究了100例年龄在2至40周的人胎盘组织。与仅对合体滋养层和中间滋养层染色的hCG和hPL不同，细胞角蛋白（AE1/AE3）对所有三种类型的滋养层组织均有染色。整个孕期胎盘组织对细胞角蛋白的染色都很强且非常一致。由于其高敏感性和对细胞滋养层的染色能力，人们认为它在植入部位病理过程的研究中可能非常有用，尤其是在从稽留流产和习惯性流产患者获取的组织中。
