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中间型滋养细胞:一种具有特定形态、生化和功能特征的独特滋养细胞形式。

Intermediate trophoblast: a distinctive form of trophoblast with specific morphological, biochemical and functional features.

作者信息

Kurman R J, Main C S, Chen H C

出版信息

Placenta. 1984 Jul-Aug;5(4):349-69. doi: 10.1016/s0143-4004(84)80015-6.

DOI:10.1016/s0143-4004(84)80015-6
PMID:6209706
Abstract

Morphological and immunohistochemical analysis of placental tissue from 12 days to term using antibodies directed against the unique carboxyl terminal peptide of human chorionic gonadotrophin beta subunit, human placental lactogen (hPL) and pregnancy-specific beta I-glycoprotein reveals that an intermediate form of trophoblast with distinctive features exists. This cell has a diverse morphological expression and is located overlying chorionic villi, in the trophoblastic columns, basal plate and the trophoblastic shell. Although all three placental proteins are localized in this cell the predominant hormone is hPL, which can serve as an immunocytochemical marker. One of the primary functions of this cell is in implantation and in the establishment of the uteroplacental circulation since it extensively invades the spiral arteries at the placental site. It is proposed that this distinctive form of trophoblast be termed 'intermediate trophoblast'.

摘要

使用针对人绒毛膜促性腺激素β亚基独特羧基末端肽、人胎盘催乳素(hPL)和妊娠特异性βI -糖蛋白的抗体,对从12天到足月的胎盘组织进行形态学和免疫组织化学分析,结果显示存在一种具有独特特征的中间型滋养层细胞。这种细胞具有多样的形态学表现,位于绒毛膜绒毛上方、滋养层柱、基底板和滋养层壳中。尽管这三种胎盘蛋白都定位于这种细胞中,但主要的激素是hPL,它可作为免疫细胞化学标记物。这种细胞的主要功能之一是参与着床和子宫胎盘循环的建立,因为它会广泛侵入胎盘部位的螺旋动脉。有人提出将这种独特形式的滋养层细胞称为“中间型滋养层细胞”。

相似文献

1
Intermediate trophoblast: a distinctive form of trophoblast with specific morphological, biochemical and functional features.中间型滋养细胞:一种具有特定形态、生化和功能特征的独特滋养细胞形式。
Placenta. 1984 Jul-Aug;5(4):349-69. doi: 10.1016/s0143-4004(84)80015-6.
2
Immunohistochemical localization of HLA antigens and placental proteins (alpha hCG, beta hCG CTP, hPL and SP1 in villous and extravillous trophoblast in normal human pregnancy: a distinctive pathway of differentiation of extravillous trophoblast.正常妊娠时人绒毛和绒毛外滋养层中HLA抗原及胎盘蛋白(α - 人绒毛膜促性腺激素、β - 人绒毛膜促性腺激素、妊娠特异性β1糖蛋白、人胎盘催乳素和SP1)的免疫组织化学定位:绒毛外滋养层独特的分化途径
Placenta. 1987 Sep-Oct;8(5):515-28. doi: 10.1016/0143-4004(87)90080-4.
3
Neoplastic and non-neoplastic intermediate trophoblasts: an immunohistochemical and ultrastructural study.肿瘤性和非肿瘤性中间型滋养细胞:一项免疫组织化学和超微结构研究。
Pathol Int. 1994 Jan;44(1):57-65. doi: 10.1111/j.1440-1827.1994.tb02586.x.
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The use of cytokeratin as a sensitive and reliable marker for trophoblastic tissue.细胞角蛋白作为滋养层组织敏感且可靠标志物的应用。
Am J Clin Pathol. 1991 Feb;95(2):137-41. doi: 10.1093/ajcp/95.2.137.
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Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor.胎盘催乳素和绒毛膜促性腺激素在正常胎盘及滋养细胞肿瘤中的免疫细胞化学定位,重点关注中间型滋养细胞和胎盘部位滋养细胞肿瘤。
Int J Gynecol Pathol. 1984;3(1):101-21. doi: 10.1097/00004347-198403010-00009.
6
[Immunohistochemical localization of hCG alpha, hCG beta CTP, hPL and SP1 on villous and extravillous trophoblasts in normal human pregnancy].[人正常妊娠时绒毛和绒毛外滋养层细胞中hCGα、hCGβ CTP、hPL和SP1的免疫组织化学定位]
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Jul;39(7):1073-9.
7
Immunolocalization of alpha and beta chains of human chorionic gonadotropin, placental lactogen and pregnancy-specific beta-glycoprotein in term placenta by a touch preparation method.采用触片制备方法对足月胎盘中人绒毛膜促性腺激素α和β链、胎盘催乳素及妊娠特异性β-糖蛋白进行免疫定位。
Histochemistry. 1987;88(1):57-60. doi: 10.1007/BF00490168.
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Immunohistochemical location of HPL, SP1 and beta-HCG in normal placentas of varying gestational age.人胎盘催乳素、SP1和β-人绒毛膜促性腺激素在不同孕周正常胎盘中的免疫组化定位。
Arch Gynecol. 1986;239(2):63-74. doi: 10.1007/BF02133965.
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Gastric choriocarcinoma; an immunohistochemical study.胃绒毛膜癌;一项免疫组织化学研究。
Pathol Res Pract. 1986 Aug;181(4):390-6. doi: 10.1016/S0344-0338(86)80073-5.
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Immunohistochemical localization of pregnancy-associated plasma protein A in decidua and trophoblast: comparison with human chorionic gonadotrophin and fibrin.妊娠相关血浆蛋白A在蜕膜和滋养层中的免疫组织化学定位:与人类绒毛膜促性腺激素和纤维蛋白的比较
Placenta. 1984 May-Jun;5(3):227-35. doi: 10.1016/s0143-4004(84)80032-6.

引用本文的文献

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Heme Oxygenase-1 Induction in Human BeWo Trophoblast Cells Decreases Proliferation in Association With the Upregulation of p38 MAPK Phosphorylation and IL-6 Production.人BeWo滋养层细胞中血红素加氧酶-1的诱导与p38丝裂原活化蛋白激酶磷酸化及白细胞介素-6产生的上调相关,从而降低细胞增殖。
Front Microbiol. 2021 Apr 12;12:659028. doi: 10.3389/fmicb.2021.659028. eCollection 2021.
2
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Toxins (Basel). 2018 Sep 13;10(9):370. doi: 10.3390/toxins10090370.
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Discovery of a cell: reflections on the checkered history of intermediate trophoblast and update on its nature and pathologic manifestations.细胞的发现:对中间滋养层曲折历史的思考及其本质和病理表现的更新
Int J Gynecol Pathol. 2014 Jul;33(4):339-47. doi: 10.1097/PGP.0000000000000144.
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Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.联合化疗用于高危妊娠滋养细胞肿瘤的初始治疗
Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4.
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Placental site trophoblastic tumor (PSTT) with multiple metastases and extremely poor prognosis.胎盘部位滋养细胞肿瘤(PSTT)伴多处转移,预后极差。
Int J Clin Oncol. 2009 Oct;14(5):452-6. doi: 10.1007/s10147-008-0860-5. Epub 2009 Oct 25.
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Placental site trophoblastic tumor.胎盘部位滋养细胞肿瘤
J Cancer Res Clin Oncol. 2008 Jan;134(1):1-6. doi: 10.1007/s00432-007-0208-y. Epub 2007 Aug 16.
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Uteroplacental blood flow. The story of decidualization, menstruation, and trophoblast invasion.子宫胎盘血流。蜕膜化、月经和滋养层侵入的故事。
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Nucleotide sequence analyses predict that human pituitary and human placental gonadotropin-releasing hormone receptors have identical primary structures.核苷酸序列分析预测,人类垂体和人类胎盘促性腺激素释放激素受体具有相同的一级结构。
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