Chernomordik Leonid V, Zimmerberg Joshua, Kozlov Michael M
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
J Cell Biol. 2006 Oct 23;175(2):201-7. doi: 10.1083/jcb.200607083. Epub 2006 Oct 16.
Despite diverse origins, cellular fusion mechanisms converge at a pathway of phospholipid bilayer fusion. In this mini-review, we discuss how proteins can mediate each of the three major stages in the fusion pathway: contact, hemifusion, and the opening of an expanding fusion pore.
尽管细胞融合机制起源多样,但都汇聚于磷脂双分子层融合途径。在这篇小型综述中,我们讨论了蛋白质如何介导融合途径中的三个主要阶段:接触、半融合以及扩展融合孔的开放。