van der Veen Erwin L, Schilder Anne G M, van Heerbeek Niels, Verhoeff Monique, Zielhuis Gerhard A, Rovers Maroeska M
Department of Otorhinolaryngology, Wilhelmina Children's Hospital, and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Arch Otolaryngol Head Neck Surg. 2006 Oct;132(10):1115-8. doi: 10.1001/archotol.132.10.1115.
To determine which factors predict development of chronic suppurative otitis media (CSOM) in children.
Case-control study, with univariate and multivariate logistic regression analysis applied to determine which factors independently predict CSOM.
Prognostic factors for CSOM were identified in (1) 100 children with CSOM and 161 controls aged 1 to 12 years and (2) 83 children who developed CSOM in the presence of a tympanostomy tube and 136 children with tympanostomy tubes who did not develop CSOM.
Independent predictors for CSOM were previous tympanostomy tube insertion (odds ratio [OR], 121.4 [95% confidence interval {CI}, 38.9-379.3]); having had more than 3 upper respiratory tract infections in the past 6 months (OR, 12.2 [95% CI, 3.5-42.3]); having parents with a low education level (OR, 14.1 [95% CI, 2.9-68.6]); and having older siblings (OR, 4.4 [95% CI, 1.6-12.6]). Independent predictors for CSOM after tympanostomy tube insertion were having experienced more than 3 episodes of otitis media in the past year (OR, 4.9 [95% CI, 2.2-11.0]; attending day care (OR, 3.6 [95% CI, 1.7-7.8]); and having older siblings (OR, 2.6 [95% CI, 1.2-5.5]).
Treatment with tympanostomy tubes is the most important prognostic factor for CSOM in children. In children who are being treated with tympanostomy tubes for persistent middle ear effusion, the most important prognostic factor for CSOM is a history of recurrent episodes of acute otitis media. This information should be taken into consideration and discussed with parents when considering insertion of tympanostomy tubes in children.
确定哪些因素可预测儿童慢性化脓性中耳炎(CSOM)的发生。
病例对照研究,应用单因素和多因素逻辑回归分析来确定哪些因素可独立预测CSOM。
在以下两组人群中确定CSOM的预后因素:(1)100例1至12岁的CSOM患儿和161例对照;(2)83例在鼓膜置管情况下发生CSOM的患儿和136例鼓膜置管但未发生CSOM的患儿。
CSOM的独立预测因素为既往鼓膜置管史(比值比[OR],121.4[95%置信区间{CI},38.9 - 379.3]);过去6个月内有超过3次上呼吸道感染(OR,12.2[95%CI,3.5 - 42.3]);父母教育水平低(OR,14.1[95%CI,2.9 - 68.6]);以及有年长的兄弟姐妹(OR,4.4[95%CI,1.6 - 12.6])。鼓膜置管后CSOM的独立预测因素为过去一年内经历超过3次中耳炎发作(OR,4.9[95%CI,2.2 - 11.0]);参加日托(OR,3.6[95%CI,1.7 - 7.8]);以及有年长的兄弟姐妹(OR,2.6[95%CI,1.2 - 5.5])。
鼓膜置管治疗是儿童CSOM最重要的预后因素。对于因持续性中耳积液而接受鼓膜置管治疗的儿童,CSOM最重要的预后因素是急性中耳炎反复发作史。在考虑为儿童插入鼓膜置管时,应考虑这些信息并与家长进行讨论。