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腺样体扁桃体切除术治疗肥胖儿童阻塞性睡眠呼吸暂停:对呼吸参数和临床结局的影响。

Adenotonsillectomy for obstructive sleep apnea in obese children: effects on respiratory parameters and clinical outcome.

作者信息

Shine Neville P, Lannigan Francis J, Coates Harvey L, Wilson Andrew

机构信息

Department of Pediatric Otolaryngology, Princess Margaret Hospital, Perth, Western Australia.

出版信息

Arch Otolaryngol Head Neck Surg. 2006 Oct;132(10):1123-7. doi: 10.1001/archotol.132.10.1123.

DOI:10.1001/archotol.132.10.1123
PMID:17043263
Abstract

OBJECTIVE

To assess the efficacy of adenotonsillar surgery on respiratory sleep parameters and avoiding continuous positive airway pressure (CPAP) treatment in morbidly obese children with obstructive sleep apnea syndrome (OSAS).

DESIGN

Retrospective.

SETTING

Tertiary referral institution.

PATIENTS

Children aged 2 to 18 years, with a body mass index (BMI) at or higher than the 95th percentile (adjusted for age and sex), undergoing adenotonsillar surgery for OSAS.

INTERVENTIONS

Adenotonsillectomy.

MAIN OUTCOME MEASURES

Preoperative and postoperative respiratory disturbance index, oxygen saturation nadir, overall severity of OSAS (mild, moderate, or severe) and candidacy for CPAP treatment were assessed and compared. Variables such as age, severity of disease, adenotonsillar size, and BMI z scores were compared between responders and nonresponders to surgical treatment.

RESULTS

A total of 19 patients with full preoperative and postoperative data for evaluation were identified. The median (SD) age was 78 months (53.3 months). The median (SD) BMI z score was 2.84 (0.94). Eighteen patients (95%) had OSAS preoperatively to warrant CPAP treatment. Surgery reduced the overall median (SD) respiratory disturbance index from 20.7 (24.5) to 7.3 (14.9) (P<.001) and improved the median (SD) oxygen saturation nadir from 77.5% (16.3%) to 88.5 (13.1%) (P<.01). A total of 7 patients (37%) were cured by surgery. Ten patients (53%) had postoperative disease of sufficient severity to require CPAP. Surgery obviated the need for further treatment in only 8 (44%) of the 18 patients with preoperative disease warranting CPAP. No differences were identified between responders and nonresponders to surgical treatment.

CONCLUSIONS

Adenotonsillar surgery improves sleep respiratory parameters in morbidly obese children with OSAS. Most patients have residual OSAS requiring further treatment.

摘要

目的

评估腺样体扁桃体手术对患有阻塞性睡眠呼吸暂停综合征(OSAS)的病态肥胖儿童呼吸睡眠参数的影响,并避免其接受持续气道正压通气(CPAP)治疗。

设计

回顾性研究。

地点

三级转诊机构。

患者

年龄在2至18岁之间、体重指数(BMI)处于或高于第95百分位数(根据年龄和性别调整)、因OSAS接受腺样体扁桃体手术的儿童。

干预措施

腺样体扁桃体切除术。

主要观察指标

评估并比较术前和术后的呼吸紊乱指数、最低血氧饱和度、OSAS的总体严重程度(轻度、中度或重度)以及CPAP治疗的适用性。对手术治疗的反应者和无反应者之间的年龄、疾病严重程度、腺样体扁桃体大小和BMI z评分等变量进行比较。

结果

共确定了19例有完整术前和术后数据可供评估的患者。中位(标准差)年龄为78个月(53.3个月)。中位(标准差)BMI z评分为2.84(0.94)。18例患者(95%)术前患有OSAS,需要CPAP治疗。手术使总体中位(标准差)呼吸紊乱指数从20.7(24.5)降至7.3(14.9)(P<0.001),并使中位(标准差)最低血氧饱和度从77.5%(16.3%)提高到88.5(13.1%)(P<0.01)。共有7例患者(37%)通过手术治愈。10例患者(53%)术后疾病严重程度足以需要CPAP治疗。在术前需要CPAP治疗的18例患者中,只有8例(44%)手术消除了进一步治疗的必要性。手术治疗的反应者和无反应者之间未发现差异。

结论

腺样体扁桃体手术可改善患有OSAS的病态肥胖儿童的睡眠呼吸参数。大多数患者仍有残余OSAS,需要进一步治疗。

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