慢性肾衰竭患者的肿瘤标志物
Tumor markers in patients with chronic renal failure.
作者信息
Filella X, Cases A, Molina R, Jo J, Bedini J L, Revert L, Ballesta A M
机构信息
Department of Clinical Biochemistry (Cancer Research Unity) Hospital Clinic i Provincial, Barcelona, Spain.
出版信息
Int J Biol Markers. 1990 Apr-Jun;5(2):85-8.
In order to evaluate the specificity of tumor markers in chronic renal failure, we have determined serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19.9 (CA 19.9), carbohydrate antigen 50 (CA 50), alphafetoprotein (AFP), neuron-specific enolase (NSE), prostatic acid phosphatase (PAP), prostatic specific antigen (PSA), squamous cell carcinoma antigen (SCC), carbohydrate antigen 15.3 (CA 15.3) and carbohydrate antigen 125 (CA 125) in 30 patients with chronic renal failure and in 36 hemodialyzed patients without clinical evidence of neoplasia. CEA, CA 50, NSE and SCC frequently show increased serum levels, suggesting a renal metabolism, while others remain, generally, within the normal levels.
为了评估肿瘤标志物在慢性肾衰竭中的特异性，我们测定了30例慢性肾衰竭患者和36例无肿瘤临床证据的血液透析患者血清中的癌胚抗原（CEA）、糖类抗原19.9（CA 19.9）、糖类抗原50（CA 50）、甲胎蛋白（AFP）、神经元特异性烯醇化酶（NSE）、前列腺酸性磷酸酶（PAP）、前列腺特异性抗原（PSA）、鳞状细胞癌抗原（SCC）、糖类抗原15.3（CA 15.3）和糖类抗原125（CA 125）水平。CEA、CA 50、NSE和SCC的血清水平经常升高，提示存在肾脏代谢，而其他标志物一般保持在正常水平。
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