Iscan Zafer H, Mavioglu Levent, Vural Kerem M, Kucuker Seref, Birincioglu Levent
Department of Cardiovascular Surgery, Yuksek Ihtisas Hospital of Turkey, Ankara, Turkey.
J Heart Valve Dis. 2006 Sep;15(5):686-90.
Cardiac surgery during pregnancy represents a major challenge as it comprises a single operation for two survivors.
Between 1988 and 2005, 16 pregnant women underwent cardiac surgery at the authors' institution. Among 14 patients with rheumatic mitral stenosis operated on due to clinical deterioration, closed mitral valvulotomy was performed in 12 cases (three urgently in the third trimester, nine at term concomitantly with cesarean delivery). Two patients underwent mitral valve replacement, again, concomitantly with cesarean delivery at term, while two others underwent emergency reoperation for mechanical valve thrombosis during the second trimester, using a strategy of high-flow, high-pressure perfusion with mild hypothermia.
A total of 12 closed mitral valvulotomies and four mitral valve replacements was performed. There was no maternal mortality, and only one stillborn occurred in the urgent closed valvulotomy group. The remaining 15 babies were born healthy.
In addition to protective perinatal procedures, instances occur during pregnancy when urgent or emergency surgery becomes unavoidable due to life-threatening cardiac decompensation. In patients with mitral stenosis, which is the case in most scenarios, closed mitral valvulotomy is life-saving and offers low fetomaternal risk, as a viable, efficient and practical alternative to percutaneous mitral balloon commissurotomy. When cardiopulmonary bypass (CPB) becomes mandatory, the shortest possible periods of mildly hypothermic or normothermic CPB with a strategy of high flow-high pressure perfusion should be followed.
孕期心脏手术是一项重大挑战,因为这是对两位幸存者进行的单次手术。
1988年至2005年间,16名孕妇在作者所在机构接受了心脏手术。在14例因临床病情恶化而接受手术的风湿性二尖瓣狭窄患者中,12例进行了闭式二尖瓣切开术(3例在孕晚期紧急进行,9例在足月时与剖宫产同时进行)。2例患者进行了二尖瓣置换术,同样在足月时与剖宫产同时进行,另外2例在孕中期因机械瓣膜血栓形成接受了急诊再次手术,采用高流量、高压灌注及轻度低温策略。
共进行了12例闭式二尖瓣切开术和4例二尖瓣置换术。无孕产妇死亡,紧急闭式二尖瓣切开术组仅发生1例死产。其余15名婴儿健康出生。
除了保护性围产期措施外,孕期还会出现因危及生命的心脏失代偿而不可避免地需要进行紧急或急诊手术的情况。在大多数情况下,对于二尖瓣狭窄患者,闭式二尖瓣切开术可挽救生命,且母婴风险低,是经皮二尖瓣球囊成形术可行、有效且实用的替代方法。当必须进行体外循环(CPB)时,应采用高流量 - 高压灌注策略,尽可能缩短轻度低温或常温CPB的时间。