Nadol'nik L I, Grivachevskiĭ A S, Petushok N E, Khomich T I, Vinogradov V V
Biomed Khim. 2006 Jul-Aug;52(4):403-12.
The activities of the antioxidant systems (AOS) and lipid peroxidation (LP) were studied in the thyroid (operation material) of patients with euthyroid nodular goiter (in carcinoma, adenoma, colloid goiter tissues as well as in non-nodular adjacent thyroid tissue). Increased activities of superoxide dismutase (SOD, by 101.0 and 125.9%), catalase (by 76.6 and 71.2%), glutathione peroxidase (by 109.6 and 249.2%), glutathione reductase (by 84.6 and 195.9%) and LP aldehyde products (by 148.5 and 120.4%) were found in the adenoma and carcinoma tissues. The increased antioxidant system activity (SOD by 1.62-fold) and LP level by 1.62-1.65--fold in the non-goiter adjacent tissue from these patients indicate toxicity of malignant and non-malignant tumors for the adjacent normal thyroid tissues. Marked activation of oxidative stress (increased SOD activity (by 38.8-40.7%) reduced glutathione (52.4-90.0%) and TBARS concentrations (37.6-52.7%) in the nodal and non-nodal thyroid tissue in patients with multinodular colloid goiter suggest participation of free radical mechanisms in the disturbance of thyrocytes iodine metabolism and development of thyroid nodular pathology.
在甲状腺功能正常的结节性甲状腺肿患者的甲状腺（手术材料）中，研究了抗氧化系统（AOS）的活性和脂质过氧化（LP）情况（在癌组织、腺瘤组织、胶样甲状腺肿组织以及相邻的非结节性甲状腺组织中）。在腺瘤和癌组织中发现超氧化物歧化酶（SOD，分别增加101.0%和125.9%）、过氧化氢酶（分别增加76.6%和71.2%）、谷胱甘肽过氧化物酶（分别增加109.6%和249.2%）、谷胱甘肽还原酶（分别增加84.6%和195.9%）以及LP醛产物（分别增加148.5%和120.4%）的活性增加。这些患者非甲状腺肿相邻组织中抗氧化系统活性增加（SOD增加1.62倍）以及LP水平增加1.62至1.65倍，表明恶性和非恶性肿瘤对相邻正常甲状腺组织具有毒性。多结节性胶样甲状腺肿患者的结节性和非结节性甲状腺组织中氧化应激明显激活（SOD活性增加38.8%至40.7%，还原型谷胱甘肽减少52.4%至90.0%，丙二醛浓度增加37.6%至52.7%），提示自由基机制参与甲状腺细胞碘代谢紊乱和甲状腺结节性病变的发生发展。
