Department of Medical Biochemistry, Tunceli Government Hospital, Turkey.
Clin Biochem. 2010 May;43(7-8):650-4. doi: 10.1016/j.clinbiochem.2010.02.005. Epub 2010 Feb 18.
We aimed to evaluate the oxidant/antioxidant status of thyroid tissue in patients with multinodular goiter, papillary carcinoma and to compare with their nonpathologic tissues.
We studied 41 patients with multinodular goiter who underwent surgical treatment. The patients were divided into three groups according to clinical diagnosis. Malondialdehyde, selenium, total superoxide dismutase and glutathione peroxidase of thyroid tissue samples were determined in 14 toxic multinodular goiters, 18 non-toxic multinodular goiters, and 9 papillary carcinomas.
Superoxide dismutase and glutathione peroxidase and selenium were found lower but malondialdehyde was higher in both nodule and cancerous tissues compared with those of control ones. The level of malondialdehyde in non-toxic multinodular goiters group was higher than toxic multinodular goiters group in nodule tissues.
It can be stated that the lipid peroxidation is increased and enzymatic free radical defense system was significantly impaired in patients with both multinodular goiters and papillary carcinomas.
我们旨在评估多结节性甲状腺肿、甲状腺乳头状癌患者甲状腺组织的氧化/抗氧化状态，并与非病变组织进行比较。
我们研究了 41 例接受手术治疗的多结节性甲状腺肿患者。根据临床诊断，将患者分为三组。测定了 14 例毒性多结节性甲状腺肿、18 例非毒性多结节性甲状腺肿和 9 例甲状腺乳头状癌患者的甲状腺组织样本中的丙二醛、硒、总超氧化物歧化酶和谷胱甘肽过氧化物酶。
与对照组相比，结节和癌组织中的超氧化物歧化酶、谷胱甘肽过氧化物酶和硒水平较低，而丙二醛水平较高。结节组织中非毒性多结节性甲状腺肿组的丙二醛水平高于毒性多结节性甲状腺肿组。
可以表明，多结节性甲状腺肿和甲状腺乳头状癌患者的脂质过氧化作用增加，酶自由基防御系统明显受损。
