Bloom D, McCalden T A, Rosendorff C
Kidney Int. 1975 Sep;8(3):149-57. doi: 10.1038/ki.1975.94.
Alterations in renal perfusion have been shown in a variety of liver diseases. We have examined the possibility that the syndrome is due to a renal vascular hypersensitivity to noradrenalin (NA). Isolated perfused kidneys and segments of rabbit femoral artery were used. Potentiation of the pressor effects of injected NA occurred in all (five artery and five kidney) preparations when jaundiced baboon plasma was perfused. These changes were significant (P less than 0.05) in nine out of the ten experiments. Controls to which normal baboon plasma was administered showed no such change. No correlation was found between the degree of NA potentiation and the plasma concentrations of bilirubin (total and conjugated), serum glutamic oxaloacetic transaminase, blood urea nitrogen, serum glutamic pyruvic transaminase, alkaline phosphatase, Na+ ions or K+ ions in the jaundiced plasma. Plasma renin levels were not significantly changed. When arteris were perfused with Krebtentiation of NA was found. Perfusion of sodium taurocholate or sodium deoxycholate (400 mug/ml) yielded no potentiation. Thus, the altered renal perfusion associated with jaundice may be attributed to a potentiated pressor response to NA which may be caused by an increased level of cholesterol carried on the beta-lipoprotein.
多种肝脏疾病已显示出肾灌注的改变。我们研究了该综合征是否由肾血管对去甲肾上腺素（NA）过敏所致。使用了兔离体灌注肾和股动脉段。当灌注黄疸狒狒血浆时，所有（五条动脉和五个肾脏）标本中注入NA的升压作用均增强。在十次实验中的九次，这些变化具有显著性（P小于0.05）。给予正常狒狒血浆的对照未显示出此类变化。在黄疸血浆中，未发现NA增强程度与胆红素（总胆红素和结合胆红素）、血清谷草转氨酶、血尿素氮、血清谷丙转氨酶、碱性磷酸酶、Na⁺离子或K⁺离子的血浆浓度之间存在相关性。血浆肾素水平无显著变化。当用Krebs液灌注动脉时，发现NA增强。灌注牛磺胆酸钠或脱氧胆酸钠（400μg/ml）未产生增强作用。因此，与黄疸相关的肾灌注改变可能归因于对NA的升压反应增强，这可能是由β-脂蛋白携带的胆固醇水平升高引起的。
