高胆固醇血症血浆对血管对去甲肾上腺素敏感性的影响。
The effects of hypercholesterolaemic plasma on vascular sensitivity to noradrenaline.
作者信息
Bloom D, McCalden T A, Rosendorff C
出版信息
Br J Pharmacol. 1975 Aug;54(4):421-7. doi: 10.1111/j.1476-5381.1975.tb07587.x.
Abstract
- The pressor responses to injected noradrenaline (NA) of 42 isolated perfused femoral arteries of the rabbit were studied. 2. Potentiation of the responses was found when hypercholesterolaemic plasma was perfused through the arteries. No change was found with normal plasma. 3. Potentiation of the responses was found when isolated beta-lipoprotein in Krebs solution was perfused. No change was found with similar amounts of bovine-albumen. 4. Pure cholesterol dissolved directly into normal plasma, and dissolved via propanol into Krebs solution or plasma caused no potentiation. Propanol alone in Krebs or plasma had no effect. 5. Potentiation was caused by a decreased equilibrium coefficient (Keq) for the NA-adrenoceptor interaction and an increased maximal pressor response (Rmax). 6. It is concluded that cholesterol carried on its apoprotein is capable of potentiating the pressor effects of noradrenaline.
摘要
- 研究了42条兔离体灌注股动脉对注射去甲肾上腺素（NA）的升压反应。2. 当通过动脉灌注高胆固醇血症血浆时，发现反应增强。灌注正常血浆时未发现变化。3. 当在 Krebs 溶液中灌注分离的β-脂蛋白时，发现反应增强。灌注等量牛血清白蛋白时未发现变化。4. 直接溶解于正常血浆中的纯胆固醇，以及通过丙醇溶解于 Krebs 溶液或血浆中的胆固醇均未引起增强作用。单独的丙醇在 Krebs 溶液或血浆中无作用。5. 增强作用是由NA-肾上腺素能受体相互作用的平衡系数（Keq）降低和最大升压反应（Rmax）增加引起的。6. 得出的结论是，载脂蛋白携带的胆固醇能够增强去甲肾上腺素的升压作用。
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