Lowenstein Daniel H
Department of Neurology, University of California, San Francisco, CA 94143, USA.
Epilepsia. 2006;47 Suppl 1:35-40. doi: 10.1111/j.1528-1167.2006.00658.x.
Refractory status epilepticus (RSE) is an important and serious clinical problem that typically requires prolonged and high-level intensive care, and is often associated with poor outcome. This review addresses some of the current issues concerning the management of RSE, including recent definitions used for clinical studies, epidemiology, clinical course, and outcome. Current approaches to treatment, including the now relatively standard use of intravenous anesthetic agents, as well as emerging therapies utilizing drugs such as valproate and topiramate, are discussed as well.
难治性癫痫持续状态（RSE）是一个重要且严重的临床问题，通常需要长期高水平的重症监护，且往往预后不良。本综述探讨了有关RSE管理的一些当前问题，包括临床研究中使用的最新定义、流行病学、临床病程及预后。还讨论了当前的治疗方法，包括目前相对标准的静脉麻醉药物使用，以及使用丙戊酸盐和托吡酯等药物的新兴疗法。
