Wang K, Peng Y
Program in Public Health Genetics, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA.
Ann Hum Genet. 2006 Nov;70(Pt 6):882-92. doi: 10.1111/j.1469-1809.2006.00277.x.
Locus heterogeneity is a concern for quantitative trait locus mapping where phenotypes are likely to be influenced by more than one gene. We introduce a model which generalizes the locus heterogeneity model of Smith (1961) from dichotomous traits to quantitative traits and consider some test statistics for this model. The type I error rates and the power of these statistics are assessed through simulation studies. These statistics are applied to a linkage study of asthma genes.
