Al-Waili Noori S, Butler Glenn J, Beale Jorge, Abdullah Mahdi S, Finkelstein Michael, Merrow Michael, Rivera Richard, Petrillo Richard, Carrey Zev, Lee Bok, Allen Michael
Life Support Technologies, Inc., NEWT Technologies, Inc., Chronic Wound Treatment and Hyperbaric Medicine Center, The Mount Vernon Hospital, New York Medical College, New York, NY 10550, USA.
Arch Med Res. 2006 Nov;37(8):991-7. doi: 10.1016/j.arcmed.2006.05.009.
We investigated the influences of hyperbaric oxygen (HBO(2)) on systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and blood glucose level (BGL).
Forty one patients with hypertension (HTN), diabetes mellitus (DM), HTN and DM and/or no HTN or DM underwent HBO(2) sessions (15-40 sessions for each patient). SBP, DBP, HR and BGL (for diabetics) were recorded before and after each session.
HBO(2) caused significant elevation in SBP (11%) and DBP (12%) and a decrease in HR (18%) (p <0.001). Patients with DM and HTN showed higher elevation in SBP and DBP. HBO(2) lowered BGL by 23% (p <0.001). When basal BGL was in the range of 120-170 mg/dl, it dropped to <100 mg/dl in 31/60 treatment sessions (52%). When basal BGL was <120 mg/dl it dropped to <70 mg/dl in 8/34 sessions. There was a possibility of lowered BGL when basal BGL was <170 mg/dl and a marked reduction in BGL occurred when basal BGL was <120 mg/dl. HBO(2) caused a marked elevation in SBP and DBP when basal SBP was >140 mmHg. Critical elevation was obtained when SBP was >160 mmHg. The use of beta blockers caused significant elevation of blood pressure while reducing HR.
HBO(2) causes elevation of blood pressure and lowering of HR and BGL, which were augmented in the presence of HTN, DM, or beta blocker. The use of beta blockers for the management of HTN should be avoided during HBO(2) therapy.
我们研究了高压氧（HBO₂）对收缩压（SBP）、舒张压（DBP）、心率（HR）和血糖水平（BGL）的影响。
41例患有高血压（HTN）、糖尿病（DM）、高血压合并糖尿病和/或无高血压或糖尿病的患者接受了HBO₂治疗（每位患者15 - 40次治疗）。每次治疗前后记录SBP、DBP、HR和（糖尿病患者的）BGL。
HBO₂导致SBP显著升高（11%）和DBP显著升高（12%），HR降低（18%）（p <0.001）。患有糖尿病和高血压的患者SBP和DBP升高幅度更大。HBO₂使BGL降低了23%（p <0.001）。当基础BGL在120 - 170mg/dl范围内时，在60次治疗中的31次（52%）降至<100mg/dl。当基础BGL<120mg/dl时，在34次治疗中的8次降至<70mg/dl。当基础BGL<170mg/dl时有可能降低BGL，而当基础BGL<120mg/dl时BGL会显著降低。当基础SBP>140mmHg时，HBO₂导致SBP和DBP显著升高。当SBP>160mmHg时达到临界升高。使用β受体阻滞剂会导致血压显著升高，同时降低心率。
HBO₂会导致血压升高以及心率和血糖水平降低，在存在高血压、糖尿病或使用β受体阻滞剂的情况下这些变化会加剧。在HBO₂治疗期间应避免使用β受体阻滞剂来治疗高血压。
