Jeyaraman Madhan, Sami Abdus, Nallakumarasamy Arulkumar, Jeyaraman Naveen, Jain Vijay Kumar
Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu 600056 India.
South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045 USA.
Indian J Orthop. 2023 Feb 9;57(5):748-761. doi: 10.1007/s43465-023-00837-2. eCollection 2023 May.
Hyperbaric oxygen therapy (HBOT) has emerged as an adjunct treatment modality in various orthopedic and rheumatological conditions. Undersea and Hyperbaric Medical Society (UHMS) defined the minimum number of HBOT cycles, dose, and frequency for various diseases. UHMS laid the 14 absolute indications for HBOT. This article deals with the mechanism of actions of HBOT and evidence of various musculoskeletal disorders where HBOT was utilized to accelerate the healing process of the diseases.
The review literature search was conducted by using PubMed, SCOPUS, and other database of medical journals for identifying, reviewing, and evaluating the published clinical trial data, research study, and review articles for the use of HBOT in musculoskeletal disorders.
Various clinical researchers documented cellular and biochemical advantages of HBOT which possess allodynic effects, anti-inflammatory, and prooxygenatory effects in patients with musculoskeletal conditions. Studies on the usage of HBOT in avascular necrosis and wound healing provide a platform for exploring the plausible uses of HBOT in other musculoskeletal conditions. Literature evidence states the complications associated with HBOT therapy.
The existing HBOT protocols have to be optimized for various musculoskeletal disorders. Large scale blinded RCTs have to be performed for demonstrating the level of evidence in the usage of HBOT in various musculoskeletal clinical scenarios.
高压氧疗法(HBOT)已成为各种骨科和风湿性疾病的辅助治疗方式。水下和高压氧医学协会(UHMS)为各种疾病定义了HBOT的最小疗程数、剂量和频率。UHMS列出了HBOT的14项绝对适应症。本文探讨了HBOT的作用机制以及在各种肌肉骨骼疾病中使用HBOT加速疾病愈合过程的证据。
通过使用PubMed、SCOPUS和其他医学期刊数据库进行文献检索,以识别、审查和评估已发表的关于HBOT在肌肉骨骼疾病中应用的临床试验数据、研究和综述文章。
各种临床研究记录了HBOT在细胞和生化方面的优势,其对肌肉骨骼疾病患者具有痛觉过敏效应、抗炎和促氧作用。关于HBOT在缺血性坏死和伤口愈合中的应用研究为探索HBOT在其他肌肉骨骼疾病中的合理用途提供了一个平台。文献证据表明了与HBOT治疗相关的并发症。
现有的HBOT方案必须针对各种肌肉骨骼疾病进行优化。必须进行大规模的双盲随机对照试验,以证明HBOT在各种肌肉骨骼临床场景中应用的证据水平。