French W J, Casaburi R, Lewis D A, Daly J A, Florio J, Wesley G W
Department of Medicine, UCLA School of Medicine, Torrance.
Pacing Clin Electrophysiol. 1990 Dec;13(12 Pt 2):1809-15. doi: 10.1111/j.1540-8159.1990.tb06895.x.
An ideal sensing variable for use in rate responsive pacemakers should measure a physiological parameter that closely correlates with heart rate during various activities in a diverse group of subjects. Nineteen patients, 12 normal and 7 patients with heart disease, were studied to assess the relationship between mixed venous oxygen saturation and heart rate. In patients with heart disease right atrial oxygen saturation and heart rate were also compared. Each subject underwent pulmonary artery catheterization and performed seated cycle ergometer exercise. Gas exchange and heart rate were measured continuously and blood sampled at frequent intervals. Normal patients were studied at rest and during steady-state exercise (mean work rate 149 watts). Patients were studied at rest, steady-state exercise (mean work rate 37 watts), and during incremental exercise (5-10 watts/min) to tolerance. There were 248 paired right atrial or mixed venous oxygen saturation/heart rate observations obtained. Changes in mixed venous oxygen saturation and heart rate were not substantially altered by fitness or cardiac disease. Rate responsive pacemakers sensing changes in oxygen saturation may be a superior sensing variable for both normal and patients with heart disease.
用于频率应答式起搏器的理想传感变量应能测量一种生理参数，该参数在不同类型的受试者进行各种活动时与心率密切相关。对19名患者进行了研究，其中12名正常人和7名心脏病患者，以评估混合静脉血氧饱和度与心率之间的关系。还比较了心脏病患者的右心房血氧饱和度和心率。每位受试者均接受了肺动脉导管插入术，并进行了坐姿蹬车运动。连续测量气体交换和心率，并频繁采集血样。对正常患者在静息状态和稳态运动（平均工作率149瓦）期间进行研究。对患者在静息状态、稳态运动（平均工作率37瓦）以及递增运动（5 - 10瓦/分钟）至耐受期间进行研究。共获得了248对右心房或混合静脉血氧饱和度/心率观察数据。混合静脉血氧饱和度和心率的变化并未因健康状况或心脏病而发生实质性改变。感知血氧饱和度变化的频率应答式起搏器对于正常人和心脏病患者而言可能都是一种更优的传感变量。
