骨关节炎股骨髁软骨体外超声分级的有效性——与组织学分级的比较
The validity of in vitro ultrasonographic grading of osteoarthritic femoral condylar cartilage--a comparison with histologic grading.
作者信息
Tsai C-Y, Lee C-L, Chai C-Y, Chen C-H, Su J-Y, Huang H-T, Huang M-H
机构信息
Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
Osteoarthritis Cartilage. 2007 Mar;15(3):245-50. doi: 10.1016/j.joca.2006.08.009. Epub 2006 Oct 11.
OBJECTIVE
To establish an ultrasonographic grading for semi-quantitative evaluation of the femoral condylar cartilage of knee osteoarthritis (OA), in vitro, and compare the ultrasonographic grading with the histologic grading.
DESIGN
Thirty-four patients going to receive total knee arthroplasty because of OA of the knee were recruited. Specimens of the distal medial and lateral femoral condyles were taken during the operation. The anterior and middle areas of the articular cartilage in each specimen were graded by in vitro ultrasonography (US) examination and histologic evaluation. The correlation between the US and histologic findings was analyzed.
RESULTS
Sixty-seven specimens were collected. Both US and histologic changes were graded from I to IV. The correlation between the grading of US and histology was good in both anterior and middle areas (Rho=0.78, 0.89, P<0.001). The correlation between US grading over anterior area and histology grading over middle area was moderate (Rho=0.70, P<0.001).
CONCLUSIONS
The moderate correlation between in vitro US and histology might permit quantitative in vivo assessment of cartilage.
目的
在体外建立一种用于膝关节骨关节炎（OA）股骨髁软骨半定量评估的超声分级方法，并将超声分级与组织学分级进行比较。
设计
招募34例因膝关节OA而准备接受全膝关节置换术的患者。术中获取股骨远端内侧和外侧髁的标本。对每个标本的关节软骨前部和中部区域进行体外超声（US）检查和组织学评估分级。分析US与组织学结果之间的相关性。
结果
共收集67个标本。US和组织学改变均分为I至IV级。在软骨前部和中部区域，US分级与组织学分级之间的相关性均良好（Rho = 0.78，0.89，P <0.001）。软骨前部区域的US分级与中部区域的组织学分级之间的相关性为中等（Rho = 0.70，P <0.001）。
结论
体外US与组织学之间的中等相关性可能允许对软骨进行定量的体内评估。
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