Stokes K, Bird T
Medtronic, Inc., Minneapolis, MN 55430.
Pacing Clin Electrophysiol. 1990 Dec;13(12 Pt 2):1901-5. doi: 10.1111/j.1540-8159.1990.tb06913.x.
The ideal lead has low, stable acute and chronic thresholds, high pacing impedance, and good sensing. Leads with low, stable thresholds have been developed, but pacing impedance has been in the 600 omega region. One way to increase pacing impedance is to decrease the electrode's surface area. The threshold performance and sensing ability of less than 5 mm2 electrodes have been considered questionable, up to now. We have developed a 1.5 mm2 porous, platinized, steroid-eluting electrode and have demonstrated in canine studies that it has excellent performance. Chronic thresholds are low at about 0.65 +/- 0.28 V (ventricular) and 0.42 +/- 0.12 V (atrial) at 0.5 msec. Chronic pacing impedance is in the 1200-1300 omega region, but mean chronic R and P wave source impedance is less than or equal to 1500 omega. Sensing is excellent, with almost double the P wave amplitudes usually measured in the canine.
理想的导线应具有低且稳定的急性和慢性阈值、高起搏阻抗以及良好的感知能力。低且稳定阈值的导线已经研发出来,但起搏阻抗一直处于600欧姆区域。增加起搏阻抗的一种方法是减小电极的表面积。到目前为止,小于5平方毫米电极的阈值性能和感知能力一直被认为存在疑问。我们研发了一种1.5平方毫米的多孔、镀铂、类固醇洗脱电极,并在犬类研究中证明其具有出色的性能。在0.5毫秒时,慢性阈值较低,心室约为0.65±0.28伏,心房约为0.42±0.12伏。慢性起搏阻抗处于1200 - 1300欧姆区域,但慢性R波和P波源阻抗的平均值小于或等于1500欧姆。感知能力极佳,P波幅度几乎是犬类通常测量值的两倍。