Aribi Ahmed, Huh Yang, Keating Michael, O'brien Susan, Ferrajoli Alessandra, Faderl Stefan, Wierda William, Kantarjian Hagop, Ravandi Farhad
Department of Leukemia, Unit 428, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Leuk Res. 2007 Jul;31(7):939-45. doi: 10.1016/j.leukres.2006.09.003. Epub 2006 Oct 12.
T-cell large granular lymphocytic (T-LGL) leukemia is characterized by cytopenia and clonal proliferation of large granular lymphocytes. We identified 26 patients with T-LGL leukemia seen at our institution over a period of 8 years. The majority of the patients were asymptomatic at diagnosis. Nine patients were treated with cyclosporine; one achieved a complete remission, and four had a hematological response. Other treatment modalities included single agent alemtuzumab, alemtuzumab combined with pentostatin, fludarabine, and combination of fludarabine and cyclophosphamide. Significant responses were not seen with any of these treatment regimens. We conclude that cyclosporine therapy may be beneficial for T-LGL leukemia patients. New treatment modalities are needed for these patients.
T细胞大颗粒淋巴细胞（T-LGL）白血病的特征是血细胞减少和大颗粒淋巴细胞的克隆性增殖。我们确定了在8年期间于我院就诊的26例T-LGL白血病患者。大多数患者在诊断时无症状。9例患者接受了环孢素治疗；1例实现完全缓解，4例有血液学反应。其他治疗方式包括单药阿仑单抗、阿仑单抗联合喷司他丁、氟达拉滨，以及氟达拉滨与环磷酰胺联合使用。这些治疗方案均未观察到显著反应。我们得出结论，环孢素治疗可能对T-LGL白血病患者有益。这些患者需要新的治疗方式。
