Anukam Kingsley C, Osazuwa Emmanuel, Osemene Gibson I, Ehigiagbe Felix, Bruce Andrew W, Reid Gregor
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Nigeria.
Microbes Infect. 2006 Oct;8(12-13):2772-6. doi: 10.1016/j.micinf.2006.08.008. Epub 2006 Sep 11.
Bacterial vaginosis (BV) is particularly common in black women, and in Nigeria it is often caused by Mycoplasma, as well as Atopobium, Prevotella and Gardnerella sp. Antimicrobial metronidazole oral therapy is poorly effective in eradicating the condition and restoring the Lactobacillus microbiota in the vagina. In this study, 40 women diagnosed with BV by discharge, fishy odor, sialidase positive test and Nugent Gram stain scoring, were randomized to receive either two dried capsules containing Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 each night for 5 days, or 0.75% metronidazole gel, applied vaginally twice a day (in the morning and evening). Follow-up at day 6, 15 and 30 showed cure of BV in significantly more probiotic treated subjects (16, 17 and 18/20, respectively) compared to metronidazole treatment (9, 9 and 11/20: P=0.016 at day 6, P=0.002 at day 15 and P=0.056 at day 30). This is the first report of an effective (90%) cure of BV using probiotic lactobacilli. Given the correlation between BV and HIV, and the high risk of the latter in Nigeria, intravaginal use of lactobacilli could provide women with a self-use therapy, similar to over-the-counter anti-yeast medication, for treatment of urogenital infections.
细菌性阴道病（BV）在黑人女性中尤为常见，在尼日利亚，它通常由支原体以及阿托波菌、普雷沃菌和加德纳菌属引起。抗菌药物甲硝唑口服治疗在根除该病症和恢复阴道内的乳酸杆菌微生物群方面效果不佳。在本研究中，40名通过分泌物、鱼腥味、唾液酸酶阳性检测和纽金特革兰氏染色评分被诊断为患有BV的女性，被随机分为两组，一组每晚服用两粒含有鼠李糖乳杆菌GR-1和罗伊氏乳杆菌RC-14的干燥胶囊，持续5天；另一组每天两次（早晚）阴道内使用0.75%的甲硝唑凝胶。在第6天、15天和30天的随访显示，与甲硝唑治疗组（分别为9例、9例和11例/20例）相比，益生菌治疗组（分别为16例、17例和18例/20例）中BV治愈的比例显著更高（第6天P=0.016，第15天P=0.002，第30天P=0.056）。这是使用益生菌乳酸杆菌有效治愈BV（治愈率90%）的首份报告。鉴于BV与艾滋病毒之间的关联，以及在尼日利亚后者的高风险，阴道内使用乳酸杆菌可为女性提供一种类似于非处方抗酵母菌药物的自我使用疗法，用于治疗泌尿生殖系统感染。
