Mitsuhashi Hiromi, Suemaru Katsuya, Li Bingjin, Cui Ranji, Araki Hiroaki
Department of Clinical Pharmacology and Pharmacy, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa Toon, Ehime, 791-0295, Japan.
Eur J Pharmacol. 2006 Dec 3;551(1-3):152-5. doi: 10.1016/j.ejphar.2006.09.005. Epub 2006 Sep 16.
Oral ulcerative mucositis is a common and painful toxicity associated with chemotherapy for cancer. Current treatment for chemotherapy-induced oral mucositis is largely palliative, and no adequate treatment with conclusive evidence exists. The purpose of this study was to evaluate the potential effectiveness of the topical external medicines used in clinical settings, and the authors investigated the effects of 1% azulene ointment, 0.12% dexamethasone ointment, and polaprezinc-sodium alginate suspension on an animal model for oral mucositis induced by chemotherapy. Oral mucositis was induced in hamsters through a combination treatment of 5-fluorouracil and mild abrasion of the cheek pouch. Each drug was administered topically to the oral mucosa of hamsters, and the process of healing of damaged oral mucositis was examined by measuring the size of the mucositis. Azulene ointment did not reduce the size of the mucositis compared with the vaseline-treated control group. Polaprezinc-sodium alginate suspension significantly improved the recovery from 5-fluorouracil-induced damage. In contrast, local treatment with dexamethasone exacerbated the mucositis markedly. These results suggested the healing effect of polaprezinc-sodium alginate suspension and the risk of steroids to severe oral mucositis induced by chemotherapy.
口腔溃疡性黏膜炎是一种与癌症化疗相关的常见且疼痛的毒性反应。目前针对化疗引起的口腔黏膜炎的治疗主要是姑息性的，尚无有确凿证据的充分治疗方法。本研究的目的是评估临床使用的外用药物的潜在疗效，作者研究了1% 薁磺酸钠软膏、0.12% 地塞米松软膏和聚锌藻酸钠混悬液对化疗诱导的口腔黏膜炎动物模型的影响。通过5-氟尿嘧啶联合颊囊轻度擦伤的方法在仓鼠中诱导口腔黏膜炎。将每种药物局部应用于仓鼠的口腔黏膜，通过测量黏膜炎的大小来检查受损口腔黏膜炎的愈合过程。与凡士林治疗的对照组相比，薁磺酸钠软膏并未减小黏膜炎的大小。聚锌藻酸钠混悬液显著改善了5-氟尿嘧啶诱导损伤的恢复情况。相比之下，地塞米松局部治疗明显加重了黏膜炎。这些结果提示了聚锌藻酸钠混悬液的愈合作用以及类固醇对化疗诱导的严重口腔黏膜炎的风险。
