金盏花局部处理加速氟尿嘧啶诱导的口腔黏膜炎仓鼠口腔黏膜愈合。
Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis.
机构信息
Stem Cell and Transgenic Technology Research Center and Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar;115(3):332-8. doi: 10.1016/j.oooo.2012.08.450. Epub 2012 Nov 20.
OBJECTIVE
This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters.
STUDY DESIGN
Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, 5% and 10% C. officinalis gel and gel base groups were treated and then compared with a control group. Macroscopic and microscopic scores and weights were evaluated.
RESULTS
Microscopic and macroscopic scores of mucositis were lower in the 5% and 10% C. officinalis gel groups than in the gel base and control groups (P < .05). Weight gain was noted in the treatment groups compared with the gel base and control groups (P < .05).
CONCLUSIONS
Calendula officinalis extract accelerated the healing of oral mucositis in hamsters.
目的
本研究评估了金盏花（Calendula officinalis）提取物局部给药对氟尿嘧啶（5-FU）诱导的仓鼠口腔黏膜炎愈合的影响。
设计
在研究的第 0、5 和 10 天，通过给予 60 只雄性仓鼠 5-FU（60mg/kg）来诱导口腔黏膜炎。在第 1 和第 2 天，用无菌针刮擦颊囊。在第 12-17 天，用 5%和 10%金盏花凝胶和凝胶基质组进行治疗，然后与对照组进行比较。评估宏观和微观评分和体重。
结果
金盏花凝胶组的黏膜炎微观和宏观评分低于凝胶基质组和对照组（P<0.05）。与凝胶基质组和对照组相比，治疗组的体重增加（P<0.05）。
结论
金盏花提取物加速了仓鼠口腔黏膜炎的愈合。
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