Department of Oral and Maxillofacial Surgery, Dental Faculty, Ondokuz Mayis University, Samsun, Turkey.
Bosn J Basic Med Sci. 2009 Nov;9(4):290-5. doi: 10.17305/bjbms.2009.2781.
The aim of this study was to describe and quantify the therapeutic value of honey in oral mucosal ulcers healing in comparison with Glyceroloxytriester (TGO). We also aimed to biochemically evaluate the healing effects of honey which had been collected from the Blacksea region flora on mucosal ulcers resulting in material loss.Thirty wistar rats (240+/-30 g) were enrolled in this study. Excisional wounds were performed in all rats for animal oral mucosal ulcer model. They were randomly allocated to three groups: group 1 was treated with Apitherapeutic agent or honey (0,1 ml, 2x1), group 2 was treated with TGO (0,1ml, 2x1) locally, Group 3 served as the control group.Following the surgical procedure on day 7, biopsy specimens were taken from right buccal mucosa and on day 14 biopsy specimens were taken from left bucal mucosa in all rats. Afterwards, hydroxy pyroline levels were measured. Data were analyzed statistically.There was no statistically significant difference between Group 1 and 2, and also between Group 2 and 3, but there was statistically significant difference between Group 1 and 3 on day 7. There was no statistically significant difference between Group 1, 2 and 3 on day 14.
本研究旨在描述和量化蜂蜜在口腔黏膜溃疡愈合方面的治疗价值，并与 Glyceroloxytriester (TGO) 进行比较。我们还旨在从黑海地区植物群中采集的蜂蜜对因物质损失而导致的黏膜溃疡的愈合效果进行生化评估。
本研究纳入了 30 只 Wistar 大鼠（240+/-30 g）。所有大鼠均进行了切除性伤口，以建立动物口腔黏膜溃疡模型。然后将它们随机分配到三组：第 1 组用蜂疗剂或蜂蜜（0.1ml，2x1）局部治疗，第 2 组用 TGO（0.1ml，2x1）局部治疗，第 3 组作为对照组。
手术后第 7 天，所有大鼠右侧颊黏膜均取活检标本，第 14 天所有大鼠左侧颊黏膜均取活检标本。然后，测量羟脯氨酸水平。数据进行统计学分析。
第 7 天，第 1 组和第 2 组、第 2 组和第 3 组之间无统计学差异，但第 1 组和第 3 组之间有统计学差异。第 14 天，第 1 组、第 2 组和第 3 组之间无统计学差异。
