Silveira V L, Limãos E A
Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, Brasil.
Agents Actions. 1990 Aug;31(1-2):143-7. doi: 10.1007/BF02003234.
During the acute phase of the inflammatory process there is a characteristic increase in some plasma proteins called collectively acute phase reactants (APR) as well as in the levels of corticosteroids. A bacterial endotoxin (LPS) that induces a strong acute phase response, indicated by high levels of fibrinogen and haptoglobin, did not show this effect when administered to rats treated previously with metopyrone, a specific inhibitor of corticosteroid hormone synthesis. These results suggest that adequate levels of these hormones are important for the production of acute phase reactants.
