Department of Physiology Escola Paulista de Medicina Universidade Federal de São Paulo São Paulo SP Brazil.
Mediators Inflamm. 1995;4(5):359-63. doi: 10.1155/S0962935195000585.
The effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and alpha(2)-macroglobulin (alpha(2)-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. alpha(2)-M was not detectable before carrageenin injection, suggesting that this putative antiinflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.
研究了富含 n-3(鱼类)和 n-6(大豆)脂肪酸的饮食对大鼠角叉菜胶足肿胀的影响,以及肾上腺、皮质酮和 α2-巨球蛋白(α2-M)在这一过程中的作用。结果发现,不仅给富含鱼油的饮食的大鼠,而且给大豆组的大鼠,角叉菜胶水肿都得到了显著抑制。α2-M 在角叉菜胶注射前检测不到,表明这种假定的抗炎因子不参与观察到的抗炎作用。在角叉菜胶刺激前,高脂肪饮食组大鼠的皮质酮水平高于对照组,肾上腺切除术消除了高脂肪饮食组动物的抗炎反应,表明肾上腺皮质激素在这一过程中起着重要作用。