Vinograd N A, Saĭitkulov A M, Tazulakhova E B, Ersnov F I
Antibiot Khimioter. 1990 Jul;35(7):32-4.
Interferon (IF)-inducing capacity of C. trachomatis was shown in experiments on mice CBA. The levels of IF production in the parenchymatous organs correlated with accumulation of the pathogen in them. The use of larifan, a natural double-stranded IF inductor, according to the treatment scheme provided high levels of endogenic IF in infected mice. It inhibited multiplication of Chlamydiae in the lungs and lymph nodes detected cytoscopically by light and fluorescence microscopy and with infection titration. The effect of the inductor combined with tetracycline was of additive nature. Double intraperitoneal administration of larifan with an account of the hyporeactivity phase and daily administration of tetracycline proved to be the most efficient. It is possible to successfully use IF inductors in accordance with the treatment schemes in infection caused by C. trachomatis which makes promising their clinical application in therapy of chlamydiosis.
在对CBA小鼠进行的实验中显示了沙眼衣原体的干扰素（IF）诱导能力。实质器官中的IF产生水平与病原体在其中的积累相关。按照治疗方案使用天然双链IF诱导剂拉里凡，可使感染小鼠体内产生高水平的内源性IF。它抑制了通过光学和荧光显微镜以及感染滴定法在细胞学上检测到的衣原体在肺和淋巴结中的繁殖。诱导剂与四环素联合使用的效果具有相加性。考虑到低反应期，腹腔注射两次拉里凡并每日给予四环素被证明是最有效的。按照治疗方案成功使用IF诱导剂来治疗沙眼衣原体感染是可能的，这使其在衣原体病治疗中的临床应用前景广阔。
