Lee Seong Hun, Kim Tae Oh, Hwang Sang Youn, Ryu Dong Yup, Lee Dong Hyun, Park Won Il, Kim Gwang Ha, Heo Jeong, Kang Dae Hwan, Song Geun Am, Cho Mong
Department of Internal Medicine, Pusan National University College of Medicine, Seo-gu, Busan, Korea.
Korean J Gastroenterol. 2006 Sep;48(3):195-9.
Rectal schwannoma is a rare mesenchymal tumor originating from Schwann's cell. We experienced a 61- year-old female patient who complained of blood tinged and narrow calibered stool for several years, and found a 4 cm sized submucosal tumor with a central ulcer on the rectal wall during colonoscopy. She underwent transanal excision. Microscopically, the tumor was composed of fasciculating bundles of spindle cells with benign nuclear atypia and peripheral lymphoid cell cuffing. Tumor cells showed a diffuse strong immunoreactivity to S-100 protein, but not stain for CD 34, desmin and smooth muscle actin. This is the first case report of rectal schwannoma in Korea.
直肠神经鞘瘤是一种罕见的起源于施万细胞的间叶组织肿瘤。我们遇到一位61岁的女性患者，她主诉多年来大便带血且便条变细，结肠镜检查时在直肠壁发现一个4厘米大小的黏膜下肿瘤，中央有溃疡。她接受了经肛门切除术。显微镜下，肿瘤由束状排列的梭形细胞组成，具有良性核异型性，周围有淋巴细胞套袖状浸润。肿瘤细胞对S-100蛋白呈弥漫性强免疫反应，但对CD 34、结蛋白和平滑肌肌动蛋白不染色。这是韩国首例直肠神经鞘瘤病例报告。
